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single Ig and TIR domain containing

Summary

Gene Symbol

Sigirr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

309106

PubChem

309106

Alliance of Genome Resources

RGD:1306732

Annotation

Keyword

Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4V892	Single Ig IL-1R-related molecule Single immunoglobulin domain-containing IL1R-related protein Toll/interleukin-1 receptor 8
A6HXP1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
biological_process	ND
cell surface receptor signaling pathway	IBA
acute-phase response	IEA ISO ISS
negative regulation of interleukin-1-mediated signaling pathway	IEA
negative regulation of Toll signaling pathway	IEA ISO ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of chemokine production [inference]

negative regulation of chemokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of chemokine production [inference]

negative regulation of chemokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of chemokine production [inference]

negative regulation of chemokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of Toll signaling pathway [inference]

negative regulation of Toll signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of Toll signaling pathway [inference]

negative regulation of Toll signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of Toll signaling pathway [inference]

negative regulation of Toll signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of chemokine production [inference]

negative regulation of chemokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of Toll signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

regulation of chemokine production [inference]

negative regulation of chemokine production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA ISO ISS
plasma membrane	IBA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

single Ig IL-1-related receptor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 6** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-1 receptor family
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Ortholog

Displaying entries **21 - 30** of 97 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Jaculus jaculus	101617685	51337_0:00037b
Mustela putorius furo	101677591		MUSPF01041
Heterocephalus glaber	101718341	10181_0:0020b7
Ficedula albicollis	101807501		FICAL12694
Mesocricetus auratus	101840054	10036_0:0001c3
Macaca fascicularis	101864854		MACFA08133
Ictidomys tridecemlineatus	101959409	43179_0:00135d	ICTTR18947
Microtus ochrogaster	101993519	79684_0:0015f8
Chinchilla lanigera	102023587	34839_0:0035ae	CHILA17683
Capra hircus	102180109		CAPHI19664

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements