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major histocompatibility complex, class II, DM beta

Summary

Gene Symbol

HLA-DMB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3109

PubChem

3109

Alliance of Genome Resources

HGNC:4935

Annotation

Keyword

3D-structure
Disulfide bond
Endosome
Glycoprotein
Immunoglobulin domain
Lysosome
MHC II
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P28068	MHC class II antigen DMB Really interesting new gene 7 protein
A0A1V0E3P2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
MHC class II protein complex assembly	IMP	8139689
peptide antigen assembly with MHC class II protein complex	IDA	22733780 23260142 7606781 9075930
peptide antigen assembly with MHC class II protein complex	IBA
antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP	8139689

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

MHC protein complex assembly [inference]

MHC class II protein complex assembly

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

MHC protein complex assembly [inference]

MHC class II protein complex assembly

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of immune effector process [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of immune response [inference]

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of immune effector process [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of immune response [inference]

positive regulation of immune response

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [inference]

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
MHC class II protein complex	IDA	22247549 22733780 7606781
MHC class II protein complex	IBA
intracellular membrane-bounded organelle	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21131964 23222639 28514442 33961781
MHC class II protein complex binding	IDA	22733780 23260142 9075930
MHC class II protein complex binding	IBA
peptide antigen binding	IBA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HLA class II histocompatibility antigen, DRB1 beta chain-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 3** entries
InterPro
MHC class II, alpha/beta chain, N-terminal
MHC class II, beta chain, N-terminal
MHC classes I/II-like antigen recognition protein

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	3109	RGD:735096
Mus musculus	14999	RGD:735096	MOUSE20108
Mus musculus	15000		MOUSE20103
Bos taurus	282491		BOVIN18261
Rattus norvegicus	294273		RATNO22107
Pan troglodytes	449592		PANTR37863
Canis lupus familiaris	607827		CANLF02613
Monodelphis domestica	100026858		MONDO12741
Equus caballus	100060996		HORSE18543
Sus scrofa	100135050		PIGXX31291

GlyTouCan

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OrthoDB (Group)

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Acknowledgements