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major histocompatibility complex, class II, DO alpha

Summary

Gene Symbol

HLA-DOA

Organism

Homo sapiens (human)

External Links

NCBI Gene

3111

PubChem

3111

Alliance of Genome Resources

HGNC:4936

Annotation

Keyword

3D-structure
Disulfide bond
Endosome
Glycoprotein
Lysosome
MHC II
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying entries **1 - 10** of 31 in total

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UniProt	Protein Name
A0A1V0E3T1
A0A1V0E3N3
A0A1V0E3Q1
A0A1V0E3S4
A0A1V0E3Q6
A0A1V0E3Q7
A0A1V0E3S6
A0A1V0E3S0
X5CF87
A0A1V0E3P9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
positive regulation of immune response	IBA
negative regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	22733780
peptide antigen assembly with MHC class II protein complex	IBA
regulation of T cell differentiation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of immune system process [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

regulation of T cell activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of immune response [inference]

positive regulation of immune response

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

regulation of immune response [inference]

positive regulation of immune response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

regulation of T cell activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

regulation of T cell activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
MHC class II protein complex	IBA IDA	22733780
plasma membrane	TAS	3000765
late endosome membrane	IBA
lysosomal membrane	IBA TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956
MHC class II protein complex binding	IBA IDA	22733780
MHC class II receptor activity	TAS	3000765
peptide antigen binding	IBA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class II receptor activity

immune receptor activity [inference]

MHC class II receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HLA class II histocompatibility antigen, DO alpha chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
adaptive immune response
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
immune system process

Displaying **all 8** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin/major histocompatibility complex, conserved site
MHC class II, alpha chain, N-terminal
MHC class II, alpha/beta chain, N-terminal
MHC classes I/II-like antigen recognition protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080820	occupational asthma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15001		MGI:95924	MOUSE20075
Rattus norvegicus	24984		RGD:3477	RATNO22178
Danio rerio	368614		ZFIN:ZDB-GENE-030616-505
Danio rerio	368816		ZFIN:ZDB-GENE-030616-323
Pan troglodytes	471979	9598_0:001d28		PANTR37874
Canis lupus familiaris	474869			CANLF02616
Danio rerio	571282		ZFIN:ZDB-GENE-081105-52
Danio rerio	641415		ZFIN:ZDB-GENE-051113-192
Danio rerio	795595		ZFIN:ZDB-GENE-131121-38
Equus caballus	100061127			HORSE18560

GlyTouCan

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LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements