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Guidelines

MIRAGE

mannose-6-phosphate receptor, cation dependent

Summary

Gene Symbol

M6pr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

312689

PubChem

312689

Alliance of Genome Resources

RGD:1359355

Annotation

Keyword

Disulfide bond
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6ILE1
Q6AY20

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein targeting to lysosome	IBA
protein targeting to lysosome	IEA
lysosomal transport	ISS
lysosomal transport	ISO
secretion of lysosomal enzymes	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IEA
endosome	ISO
endosome	IEA
late endosome	ISO
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein domain specific binding	IEA
retromer complex binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein domain specific binding

protein-containing complex binding [inference]

retromer complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannose-6-phosphate receptor, cation dependent

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MRH domain
Mannose-6-phosphate receptor binding domain superfamily
Mannose-6-phosphate receptor

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4074	Xenbase:XB-GENE-991688	HUMAN11060
Mus musculus	17113	Xenbase:XB-GENE-991688	MOUSE47430
Bos taurus	281291		BOVIN30326
Xenopus tropicalis	312689	Xenbase:XB-GENE-991688
Danio rerio	406486		DANRE10575
Takifugu rubripes	654276		TAKRU45859
Macaca mulatta	716696		MACMU04704
Pan troglodytes	736013		PANTR05101
Monodelphis domestica	100012242		MONDO33661
Sus scrofa	100154117		PIGXX26225

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025