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ciliary neurotrophic factor receptor

Summary

Gene Symbol

Cntfr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

313173

PubChem

313173

Alliance of Genome Resources

RGD:1303100

Annotation

Keyword

Cell membrane
Disulfide bond
GPI-anchor
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6IIW4
A0A8I5Y668
Q08406

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
motor neuron apoptotic process	IEA ISO
negative regulation of motor neuron apoptotic process	IEA ISO
sex differentiation	IEA ISO
negative regulation of neuron apoptotic process	ISO
cytokine-mediated signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

ciliary neurotrophic factor-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

reproductive process [inference]

developmental process involved in reproduction [inference]

sex differentiation

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

suckling behavior

developmental process [inference]

developmental process involved in reproduction [inference]

sex differentiation

anatomical structure development [inference]

brainstem development

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

ciliary neurotrophic factor-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
apical plasma membrane	IEA ISO
plasma membrane	IEA
CNTFR-CLCF1 complex	IBA IEA ISO
ciliary neurotrophic factor receptor complex	IBA IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

CNTFR-CLCF1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IEA ISO
cytokine receptor activity	IBA IEA
ciliary neurotrophic factor receptor activity	IEA IMP ISO	8381290
cytokine binding	IBA IEA IPI ISO	1648265

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

immune receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

ciliary neurotrophic factor receptor subunit alpha

Functional Category

T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
ciliary neurotrophic factor receptor activity
cytokine-mediated signaling pathway

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Long hematopoietin receptor, soluble alpha chain, conserved site

Ortholog

Displaying entries **71 - 80** of 99 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Peromyscus leucopus	114703234	10041_0:000e37
Echeneis naucrates	115051930		ECHNA50691
Salmo trutta	115160200		SALTR70183
Salmo trutta	115191022		SALTR49005
Salarias fasciatus	115383273		SALFA14017
Mastomys coucha	116095849	35658_0:001b96
Corvus moneduloides	116437999		CORMO28385
Chelonoidis abingdonii	116825131		CHEAB21959
Rattus rattus	116891327	10117_0:00021d
Rhinolophus ferrumequinum	117031925		RHIFE21034

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OrthoDB (Group)

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Acknowledgements