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complement C8 beta chain

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

313421

PubChem

313421

Alliance of Genome Resources

RGD:2239

Annotation

Keyword

Complement alternate pathway
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JRT7	Complement component 8 subunit beta
P55314	Complement component 8 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
complement activation, alternative pathway	IEA
killing of cells of another organism	IEA
complement activation, classical pathway	IEA
complement activation	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane attack complex	IBA IEA ISO
extracellular region	IDA IEA	3312411
extracellular space	IBA IDA	3312411

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
protein-containing complex binding	IPI	3312411

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

complement component C8 beta chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying **all 8** entries
InterPro
Complement components C8A/B/C6, EGF-like domain
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin/complement C9
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
extracellular space	PMID:3312411
extracellular region	PMID:3312411

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060302	type II complement component 8 deficiency	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	732		HGNC:1353	HUMAN50094
Mus musculus	110382	10090_1:0014eb	MGI:88236	MOUSE41884
Pan troglodytes	456887			PANTR21215
Canis lupus familiaris	479555			CANLF15663
Bos taurus	513217			BOVIN26860
Macaca mulatta	716155			MACMU24082
Danio rerio	793127		ZFIN:ZDB-GENE-070912-163	DANRE30179
Sus scrofa	100037954			PIGXX30289
Equus caballus	100059423			HORSE26947
Taeniopygia guttata	100222207			TAEGU29316

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OrthoDB (Group)

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Acknowledgements