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major histocompatibility complex, class I-related

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3140

PubChem

3140

Alliance of Genome Resources

HGNC:4975

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Immunoglobulin domain
Innate immunity
MHC I
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q95460	Class I histocompatibility antigen-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of peptide antigen via MHC class I	IEA
positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA	31959982
immune response	IBA
antigen processing and presentation of exogenous antigen	IDA	27043408
T cell differentiation in thymus	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

antigen processing and presentation [inference]

antigen processing and presentation of exogenous antigen

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
extracellular space	IBA
endoplasmic reticulum	IDA	21190736
endoplasmic reticulum membrane	IDA	27043408
plasma membrane	IDA	27043408

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class I protein complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23051753 25416956 27043408 32296183
beta-2-microglobulin binding	IDA	26795251
MHC class I receptor activity	TAS	7624800
T cell receptor binding	IDA	26795251

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

T cell receptor binding

beta-2-microglobulin binding

protein-containing complex binding [inference]

T cell receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class I receptor activity

immune receptor activity [inference]

MHC class I receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

class i histocompatibility

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
MHC class I-like antigen recognition-like superfamily
MHC class I-like antigen recognition-like
MHC classes I/II-like antigen recognition protein

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	563	ZFIN:ZDB-GENE-130206-9
Danio rerio	909	ZFIN:ZDB-GENE-140820-7
Danio rerio	910	ZFIN:ZDB-GENE-140820-7
Danio rerio	911	ZFIN:ZDB-GENE-140820-7
Danio rerio	912	ZFIN:ZDB-GENE-140820-7
Danio rerio	913	ZFIN:ZDB-GENE-140820-7
Danio rerio	2217	ZFIN:ZDB-GENE-140820-7
Danio rerio	3077	ZFIN:ZDB-GENE-140820-7
Xenopus tropicalis	3105	Xenbase:XB-GENE-5873924
Xenopus tropicalis	3106	Xenbase:XB-GENE-5873924

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements