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Guidelines

MIRAGE

3-hydroxy-3-methylglutaryl-CoA lyase

Summary

Gene Symbol

HMGCL

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 317658
KEGG Gene ID: bta:317658
PubChem: 317658

Annotation

Keyword

Acetylation
Disulfide bond
Lipid metabolism
Lyase
Metal-binding
Mitochondrion
Peroxisome
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q29448	3-hydroxy-3-methylglutarate-CoA lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
leucine catabolic process	IEA	30032202
ketone body biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

ketone body biosynthetic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA lyase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

hydroxymethylglutaryl-CoA lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydroxymethylglutaryl-coA lyase

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 6** entries
Gene Ontology
catalytic activity
hydroxymethylglutaryl-CoA lyase activity
ketone body biosynthetic process
leucine catabolic process
metal ion binding
oxo-acid-lyase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
HMG-CoA lyase
Pyruvate carboxyltransferase

KEGG BRITE Database

Orthology

K01640

Name

hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]

References

17692550

Rhea

(3S)-hydroxy-3-methylglutaryl-CoA

acetoacetate + acetyl-CoA

Enzyme

4.1.3.4

PMID

Ortholog

Displaying entries **1 - 10** of 73 in total

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3155		HUMAN48065
Mus musculus	15356		MOUSE40990
Rattus norvegicus	79238		RATNO32707
Danio rerio	394190		DANRE11672
Pan troglodytes	456624		PANTR20240
Macaca mulatta	710833		MACMU22253
Monodelphis domestica	100010594		MONDO24952
Equus caballus	100057686		HORSE27468
Ornithorhynchus anatinus	100089310		ORNAN08412
Taeniopygia guttata	100217934		TAEGU13529

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Last updated: December 8, 2025