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heterogeneous nuclear ribonucleoprotein A2/B1

Summary

Gene Symbol

HNRNPA2B1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3181

PubChem

3181

Alliance of Genome Resources

HGNC:5033

JoGo

HNRNPA2B1

TogoVar

HNRNPA2B1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Host-virus interaction
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Ribonucleoprotein
Secreted
Spliceosome
Ubl conjugation
mRNA transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P22626
A0A7I2V4N1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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2

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GO Term	Evidence Code	PMID
mRNA splicing, via spliceosome	IC	11991638 9731529
mRNA splicing, via spliceosome	IMP	26321680
mRNA splicing, via spliceosome	IBA
mRNA processing	IDA	2557628
mRNA export from nucleus	IDA	10567417

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing [inference]

primary miRNA processing

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change

G-quadruplex DNA unwinding

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport

mRNA export from nucleus

miRNA transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport

mRNA export from nucleus

miRNA transport

establishment of RNA localization [inference]

RNA transport

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport

mRNA export from nucleus

miRNA transport

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	ISS
nucleus	IDA	22720776
nucleoplasm	TAS
nucleoplasm	IDA
spliceosomal complex	IDA	9731529

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex

catalytic step 2 spliceosome

catalytic complex [inference]

catalytic step 2 spliceosome

ribonucleoprotein complex

spliceosomal complex

catalytic step 2 spliceosome

cellular anatomical entity [inference]

nuclear body [inference]

Cajal body

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
RNA binding	IDA	15659580
RNA binding	HDA	22658674 22681889
mRNA 3'-UTR binding	IDA	10567417
mRNA 3'-UTR binding	IBA
protein binding	IPI	15703215 17289661 18519039 21784977 22720776 23976881 24549040 24965446 25678563 25702638 26321680 26496610 30021884 35271311 36950384 37207277 37643469

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

DNA polymerase binding

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding [inference]

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

sequence-specific DNA binding [inference]

telomeric DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

RNA binding

mRNA binding [inference]

mRNA 3'-UTR binding

regulatory RNA binding [inference]

miRNA binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-RNA adaptor activity [inference]

N6-methyladenosine-containing RNA reader activity

molecular condensate scaffold activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heterogeneous nuclear ribonucleoprotein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050881	inclusion body myopathy with Paget disease of bone and frontotemporal dementia	Alliance of Genome Resources
DOID:0111384	inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements