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neuronal cell adhesion molecule

Summary

Gene Symbol

Nrcam

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

319504

PubChem

319504

Alliance of Genome Resources

MGI:104750

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q810U4	Neuronal surface protein Bravo NgCAM-related cell adhesion molecule
Q6QRP1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
homophilic cell adhesion via plasma membrane adhesion molecules	IBA
axon guidance	IDA	12182881
axon guidance	IBA
central nervous system development	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

heterotypic cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

retinal ganglion cell axon guidance

membrane organization [inference]

neuronal ion channel clustering [inference]

clustering of voltage-gated sodium channels

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuronal action potential propagation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

system development [inference]

central nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of synapse organization [inference]

regulation of postsynapse organization

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

action potential propagation [inference]

neuronal action potential propagation

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	TAS
plasma membrane	IDA	16882004
plasma membrane	IBA
axon	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

axon initial segment

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16882004 23897819
ankyrin binding	ISS
ankyrin binding	ISO
protein binding involved in heterotypic cell-cell adhesion	IGI	20188654
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

ankyrin binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

protein binding involved in heterotypic cell-cell adhesion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cell adhesion molecule

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
brain development
cell-cell adhesion mediator activity

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neurofascin/L1/NrCAM, C-terminal domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3897	FB:FBgn0264975
Homo sapiens	4897	Xenbase:XB-GENE-489769	HUMAN90805
Drosophila melanogaster	10752	FB:FBgn0264975
Drosophila melanogaster	12661	FB:FBgn0264975
Drosophila melanogaster	16728	FB:FBgn0264975
Drosophila melanogaster	23114	FB:FBgn0264975
Xenopus tropicalis	31792	Xenbase:XB-GENE-489769
Drosophila melanogaster	50687	FB:FBgn0264975
Drosophila melanogaster	116690	FB:FBgn0264975
Xenopus tropicalis	177078	Xenbase:XB-GENE-489769

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements