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amyloid beta precursor protein binding family A member 1

Summary

Gene Symbol

APBA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

320

PubChem

320

Alliance of Genome Resources

HGNC:578

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Golgi apparatus
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02410	Adapter protein X11alpha Neuron-specific X11 protein Neuronal Munc18-1-interacting protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IEA
intracellular protein transport	IEA
cell adhesion	TAS	9753324
chemical synaptic transmission	IBA
nervous system development	TAS	9753324

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

export from cell [inference]

secretion by cell [inference]

glutamate secretion

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

behavior [inference]

locomotory behavior

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

system development [inference]

nervous system development

growth [inference]

developmental growth [inference]

multicellular organism growth

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

glutamate secretion

acid secretion [inference]

gamma-aminobutyric acid secretion

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

gamma-aminobutyric acid transport [inference]

gamma-aminobutyric acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

gamma-aminobutyric acid transport [inference]

gamma-aminobutyric acid secretion

nitrogen compound transport [inference]

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

gamma-aminobutyric acid transport [inference]

gamma-aminobutyric acid secretion

protein transport [inference]

intracellular protein transport

amide transport [inference]

glutamate secretion

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport

export from cell [inference]

secretion by cell [inference]

glutamate secretion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IBA
Golgi apparatus	IDA
cytosol	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

perinuclear region of cytoplasm

postsynapse [inference]

dendritic spine

Displaying **all 2** entries
GO Term	Evidence Code	PMID
amyloid-beta binding	IBA
protein binding	IPI	11083918 16007100 20531236 21763699 23737971 31413325 33961781 35914814 8887653

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amyloid beta A4 precursor protein-binding family A member 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
amyloid-beta binding
chemical synaptic transmission

Displaying **all 4** entries
InterPro
PDZ domain
PDZ superfamily
PH-like domain superfamily
PTB/PI domain

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	320	Xenbase:XB-GENE-977639
Rattus norvegicus	83589		RATNO19642
Mus musculus	319924		MOUSE24888
Pan troglodytes	472947		PANTR44075
Macaca mulatta	699838		MACMU12802
Danio rerio	100003938		DANRE36192
Monodelphis domestica	100015487		MONDO28688
Ornithorhynchus anatinus	100074054		ORNAN32430
Taeniopygia guttata	100223129		TAEGU30768
Callithrix jacchus	100390315		CALJA19005