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alpha1,6-fucosyltransferase

Summary

Gene Symbol

FucT6

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

32122

KEGG Gene ID

dme:Dmel_CG2448

PubChem

32122

Alliance of Genome Resources

FB:FBgn0030327

Annotation

Keyword

Disulfide bond
Glycosyltransferase
Golgi apparatus
Magnesium
Manganese
Metal-binding
Reference proteome
SH3 domain
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VYV5	GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-glycan fucosylation	IBA
GDP-L-fucose metabolic process	ISS
protein glycosylation	IEA
protein N-linked glycosylation via asparagine	ISS
protein N-linked glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

glycosylation [inference]

fucosylation [inference]

N-glycan fucosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-(1->6)-fucosyltransferase activity	IBA IDA	15604090
metal ion binding
glycoprotein 6-alpha-L-fucosyltransferase activity	IEA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

alpha-(1->6)-fucosyltransferase activity

glycoprotein 6-alpha-L-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein 6-alpha-L-fucosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
N-glycan fucosylation
alpha-(1->6)-fucosyltransferase activity
hexosyltransferase activity
protein N-linked glycosylation
transferase activity

Displaying **all 5** entries
InterPro
Alpha-(1,6)-fucosyltransferase, N- and catalytic domain
Alpha-(1,6)-fucosyltransferase, SH3 domain
Glycosyltransferase family 23 (GT23) domain
SH3 domain
SH3-like domain superfamily

KEGG BRITE Database

Orthology

K00717

Name

glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]

References

8910378

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R09319	2.4.1.68	G61751GZ	G07483YN
R05988	2.4.1.68	G39213VZ	G80858MF

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Rhea

RHEA:12985

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.68

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Drosophila grimshawi	6566252	7222_1:002c27
Drosophila mojavensis	6585401	7230_1:0005fe
Drosophila persimilis	6600409	7234_1:002f0b
Drosophila sechellia	6619899	7238_0:0027ba
Drosophila virilis	6634811	7244_1:000616
Drosophila willistoni	6641223	7260_0:000d72
Drosophila simulans	6725700	7240_1:00314d
Danio rerio	100331714		ZFIN:ZDB-GENE-130530-923
Drosophila suzukii	108005467	28584_0:0028fa
Drosophila biarmipes	108032631	125945_1:0005e5

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Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements