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hepsin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3249

KEGG Gene ID

PubChem

3249

Alliance of Genome Resources

HGNC:5155

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P05981	Transmembrane protease serine 1
A0A140VJK9	Transmembrane protease serine 1
B7Z1L4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 20 in total

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GO Term	Evidence Code	PMID
negative regulation of epithelial to mesenchymal transition	IDA
positive regulation of plasminogen activation	IDA
protein processing	IBA
positive regulation of cell growth	IMP
basement membrane disassembly	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

detection of mechanical stimulus involved in sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

cochlea morphogenesis

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

host-mediated perturbation of symbiont process [inference]

host-mediated perturbation of viral process [inference]

host-mediated perturbation of viral transcription [inference]

host-mediated activation of viral transcription

host-mediated activation of viral process [inference]

host-mediated activation of viral transcription

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

reflex [inference]

pilomotor reflex

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone

response to chemical [inference]

response to hormone [inference]

response to thyroid hormone

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

negative regulation of epithelial cell proliferation

regulation of hepatocyte proliferation [inference]

positive regulation of hepatocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of plasminogen activation

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of biological quality [inference]

regulation of cell shape

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IDA
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA
serine-type endopeptidase activity	IEA
protein binding	IPI
peptidase activity	IDA
serine-type peptidase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1059	intellectual disability	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	15451	MGI:1196620
Rattus norvegicus	29135	RGD:61982

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements