hypoxanthine phosphoribosyltransferase 1
| UniProt | Protein Name |
|---|---|
| A0A140VJL3 |
|
| P00492 |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| T cell mediated cytotoxicity | ||
| response to amphetamine | ||
| purine nucleotide biosynthetic process | ||
| purine ribonucleoside salvage | ||
| guanine salvage |
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleotide binding | ||
| magnesium ion binding | ||
| magnesium ion binding | ||
| hypoxanthine phosphoribosyltransferase activity | ||
| hypoxanthine phosphoribosyltransferase activity |
| Gene Ontology |
|---|
| GMP salvage |
| IMP salvage |
| guanine phosphoribosyltransferase activity |
| guanine salvage |
| hypoxanthine metabolic process |
| hypoxanthine phosphoribosyltransferase activity |
| magnesium ion binding |
| metal ion binding |
| nucleotide binding |
| purine ribonucleoside salvage |
| InterPro |
|---|
| Hypoxanthine phosphoribosyl transferase |
| Phosphoribosyltransferase domain |
| Phosphoribosyltransferase-like |
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112127 | HRPT-related hyperuricemia | |
| DOID:1919 | Lesch-Nyhan syndrome |
| HPO ID | HPO Term |
|---|---|
| HP:0000029 | Testicular atrophy |
| HP:0000083 | Renal insufficiency |
| HP:0000112 | Nephropathy |
| HP:0000121 | Nephrocalcinosis |
| HP:0000707 | Abnormality of the nervous system |
| HP:0000708 | Atypical behavior |
| HP:0000742 | Self-mutilation |
| HP:0000787 | Nephrolithiasis |
| HP:0000790 | Hematuria |
| HP:0000791 | Uric acid nephrolithiasis |
| Disease ID | Disease Name |
|---|---|
| ORPHA:510 |
|
| OMIM:300323 |
|
| OMIM:300322 |
|
| ORPHA:79233 |
|
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 105732276 | AOTNA36506 | ||
| 105817690 | PROCO06327 | ||
| 107560739 | SINGR17947 | ||
| 107601120 | SINGR64529 | ||
| 108268988 | ICTPU33597 | ||
| 109310997 | CROPO18605 | ||
| 112927879 | VULVU22395 | ||
| 113446755 | PSETE20102 | ||
| 115049604 | ECHNA29971 | ||
| 115205547 | SALTR113142 |
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
This work is licensed under Creative Commons Attribution 4.0 International
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Last updated: December 8, 2025