GlyCosmos Portal

Submissions

Structural maintenance of chromosomes 3

Summary

Gene Symbol

SMC3

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

32627

KEGG Gene ID

dme:Dmel_CG9802

PubChem

32627

Alliance of Genome Resources

FB:FBgn0015615

Annotation

Keyword

ATP-binding
Acetylation
Centromere
Chromosome
Coiled coil
DNA repair
Meiosis
Mitosis
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VXE9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
establishment of imaginal disc-derived wing hair orientation	IMP	22563761
mitotic sister chromatid cohesion	IBA
imaginal disc-derived wing morphogenesis	IMP	22563761
chromosome organization	IEA

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of imaginal disc-derived wing hair orientation

post-embryonic animal morphogenesis [inference]

establishment of imaginal disc-derived wing hair orientation

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
chromosome	IEA
cohesin complex	IDA	15375666
mitotic cohesin complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

cohesin complex

mitotic cohesin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
chromatin binding	ISS
double-stranded DNA binding	IBA
ATP binding	IEA
ATP hydrolysis activity	ISS
ATP hydrolysis activity	NAS	11864377

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

structural maintenance of

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
ATP binding
cell division
cohesin loader activity
double-stranded DNA binding
mitotic sister chromatid cohesion

Displaying **all 6** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
RecF/RecN/SMC, N-terminal
SMCs flexible hinge superfamily
SMCs flexible hinge
Structural maintenance of chromosomes 3, ABC domain, eukaryotic
Structural maintenance of chromosomes protein

KEGG BRITE Database

Orthology

K06669

Name

structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)

References

11076961

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cohesin complex	PMID:15375666

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080507	Cornelia de Lange syndrome 3	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements