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Structural maintenance of chromosomes 3

Summary

Gene Symbol

SMC3

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

32627

KEGG Gene ID

dme:Dmel_CG9802

PubChem

32627

Alliance of Genome Resources

FB:FBgn0015615

Annotation

Keyword

Coiled coil
Mitosis
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VXE9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitotic sister chromatid cohesion	IBA
establishment of imaginal disc-derived wing hair orientation	IMP	22563761
chromosome organization	IEA
imaginal disc-derived wing morphogenesis	IMP	22563761

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of imaginal disc-derived wing hair orientation

post-embryonic animal morphogenesis [inference]

establishment of imaginal disc-derived wing hair orientation

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
chromosome	IEA
mitotic cohesin complex	IBA
cohesin complex	IDA	15375666

GO Hierarchy

cellular component

protein-containing complex [inference]

cohesin complex

mitotic cohesin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
double-stranded DNA binding	IBA
chromatin binding	ISS
ATP binding	IEA
ATP hydrolysis activity	IEA ISS NAS	11864377
protein heterodimerization activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K06669

Name

structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)

References

11076961

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cohesin complex	PMID:15375666

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080507	Cornelia de Lange syndrome 3	Alliance of Genome Resources
DOID:1059	intellectual disability	Alliance of Genome Resources
DOID:11725	Cornelia de Lange syndrome	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	176559	WB:WBGene00004873
Danio rerio	324475	ZFIN:ZDB-GENE-030131-3196
Xenopus tropicalis	100145671	Xenbase:XB-GENE-957583
Homo sapiens	9126	HGNC:2468
Mus musculus	13006	MGI:1339795
Rattus norvegicus	29486	RGD:62006
Saccharomyces cerevisiae S288C	853371	SGD:S000003610

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements