GlyCosmos Portal

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Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

32661

PubChem

32661

Alliance of Genome Resources

FB:FBgn0001250

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Integrin
Olfaction
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P12080	Position-specific antigen subunit alpha-2 Protein inflated

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
cell adhesion	IEA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS	10908592
cell-matrix adhesion	ISS	10908592
cell-matrix adhesion	IBA
integrin-mediated signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell adhesion mediated by integrin

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell recognition [inference]

neuron recognition [inference]

axonal defasciculation

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

hemocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

supramolecular fiber organization [inference]

myofibril assembly

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of smell

muscle attachment

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of epithelial integrity, open tracheal system

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

apposition of dorsal and ventral imaginal disc-derived wing surfaces

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

central nervous system morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development [inference]

ventral cord development

gland development [inference]

salivary gland development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of epithelial integrity, open tracheal system

localization [inference]

maintenance of location [inference]

maintenance of protein location

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

maintenance of epithelial integrity, open tracheal system

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	16569666 7972082
focal adhesion	IDA	19903692
integrin complex	ISS	10908592
integrin complex	NAS	14519396
integrin complex	TAS	10936444

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

lateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
integrin binding	IBA
protein heterodimerization activity	IPI	7972082
extracellular matrix binding	IDA	7972082
extracellular matrix protein binding	IPI	7924982

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

protein dimerization activity [inference]

protein heterodimerization activity

cell adhesion molecule binding [inference]

integrin binding

extracellular matrix protein binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
cell adhesion mediated by integrin
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 9** entries
InterPro
FG-GAP repeat
Integrin alpha beta-propellor
Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Integrin alpha chain
Integrin alpha, N-terminal
Integrin alpha, first immunoglubulin-like domain
Integrin alpha, second immunoglobulin-like domain
Integrin alpha, third immunoglobulin-like domain
Integrin domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
focal adhesion	PMID:19903692
membrane	FB:FBrf0231198
plasma membrane	PMID:16569666 PMID:7972082
sarcolemma	PMID:11784030
integrin complex	PMID:7972082
basal plasma membrane	PMID:8898242

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1059	intellectual disability	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	3674	Xenbase:XB-GENE-5950162
Xenopus tropicalis	3678	Xenbase:XB-GENE-493953
Xenopus tropicalis	3685	Xenbase:XB-GENE-488969
Xenopus tropicalis	8516	Xenbase:XB-GENE-961825
Xenopus tropicalis	16399	Xenbase:XB-GENE-5950162
Xenopus tropicalis	16402	Xenbase:XB-GENE-493953
Xenopus tropicalis	16410	Xenbase:XB-GENE-488969
Xenopus tropicalis	32661	Xenbase:XB-GENE-493953
Xenopus tropicalis	176240	Xenbase:XB-GENE-493953
Xenopus tropicalis	241226	Xenbase:XB-GENE-961825