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cellular communication network factor 6

Summary

Gene Symbol

Ccn6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

327743

PubChem

327743

Alliance of Genome Resources

MGI:2685581

Annotation

Keyword

Disulfide bond
Glycoprotein
Growth factor
Mitochondrion
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
D3Z5L9	CCN family member 6 WNT1-inducible-signaling pathway protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cell adhesion	IBA
signal transduction	IBA
signal transduction	IEA
negative regulation of cell population proliferation	ISO
negative regulation of angiogenesis	ISO

GO Hierarchy

biological process

cellular process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA
mitochondrion	ISS
mitochondrion	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
integrin binding	IBA
growth factor activity	IEA
heparin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

receptor ligand activity [inference]

growth factor activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ccn

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
heparin binding
integrin binding

Displaying **all 9** entries
InterPro
CCN, TSP1 domain
Cystine knot, C-terminal
Glycoprotein hormone subunit beta
Growth factor receptor cysteine-rich domain superfamily
IGFBP-related, CNN
Insulin-like growth factor-binding protein, IGFBP
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat
VWFC domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090004	progressive pseudorheumatoid arthropathy of childhood	Alliance of Genome Resources
DOID:4680	breast metaplastic carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1490	FB:FBgn0052183
Drosophila melanogaster	3491	FB:FBgn0052183
Drosophila melanogaster	4856	FB:FBgn0052183
Homo sapiens	8838	Xenbase:XB-GENE-967531	HUMAN86163
Drosophila melanogaster	8840	FB:FBgn0052183
Drosophila melanogaster	18133	FB:FBgn0052183
Drosophila melanogaster	22402	FB:FBgn0052183
Drosophila melanogaster	22403	FB:FBgn0052183
Drosophila melanogaster	29576	FB:FBgn0052183
Drosophila melanogaster	65154	FB:FBgn0052183

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements