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hydroxysteroid 11-beta dehydrogenase 2

Summary

Gene Symbol

HSD11B2

Aliases

SDR9C3
short chain dehydrogenase/reductase family 9C, member 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3291

HGNC

5209

KEGG Gene ID

hsa:3291

PubChem

3291

Alliance of Genome Resources

HGNC:5209

Annotation

Keyword

Direct protein sequencing
Disease variant
Microsome
NAD
Oxidoreductase
Reference proteome
Steroid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
P80365	11-beta-hydroxysteroid dehydrogenase type II Corticosteroid 11-beta-dehydrogenase isozyme 2 NAD-dependent 11-beta-hydroxysteroid dehydrogenase Short chain dehydrogenase/reductase family 9C member 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
regulation of blood volume by renal aldosterone	IEA
female pregnancy	IEA
glucocorticoid metabolic process	IBA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cortisol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

cellular ketone metabolic process [inference]

cortisol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cortisol metabolic process

cellular ketone metabolic process [inference]

cortisol metabolic process

olefinic compound metabolic process [inference]

cortisol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

glucocorticoid metabolic process

cortisol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renal system process involved in regulation of blood volume [inference]

regulation of blood volume by renal aldosterone

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of blood volume by renal aldosterone

multi-multicellular organism process [inference]

female pregnancy

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to food

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to food

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of blood volume by renal aldosterone

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure [inference]

regulation of blood volume by renal aldosterone

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
intracellular membrane-bounded organelle	IDA
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
steroid binding	IEA
NAD binding	IEA
11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IMP	8538347
11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NAD+) activity

binding [inference]

lipid binding [inference]

steroid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

steroid binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Estradiol 17-beta-dehydrogenase 2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity
steroid metabolic process

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR
Short-chain dehydrogenase/reductase, conserved site

Human Protein Atlas

ENSG00000176387

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00071

Name

corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]

References

18573267

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:4367	apparent mineralocorticoid excess syndrome	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **11 - 20** of 22 in total

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HPO ID	HPO Term
HP:0001712	Left ventricular hypertrophy
HP:0001959	Polydipsia
HP:0001960	Hypokalemic metabolic alkalosis
HP:0002900	Hypokalemia
HP:0003351	Decreased circulating renin level
HP:0004319	Decreased circulating aldosterone level
HP:0004322	Short stature
HP:0011463	Childhood onset
HP:0011731	Abnormality of circulating cortisol level
HP:0012603	Abnormal urine sodium concentration

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:320	apparent mineralocorticoid excess
OMIM:218030	apparent mineralocorticoid excess

PubChem Disease

MedGen Diseases

Apparent mineralocorticoid excess

OMIM Phenotypes

APPARENT MINERALOCORTICOID EXCESS; AME

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000140
Gene Name: hydroxysteroid (11-beta) dehydrogenase 2

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3291	Xenbase:XB-GENE-1012826
Mus musculus	15484		MOUSE60250
Rattus norvegicus	25117		RATNO14852
Danio rerio	334098		DANRE40572
Sus scrofa	396948		PIGXX27366
Pan troglodytes	468001		PANTR12609
Macaca mulatta	574396		MACMU26726
Equus caballus	100034124		HORSE31017
Ornithorhynchus anatinus	100081477		ORNAN29040
Oryzias latipes	100125474		ORYLA12058

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements