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heat shock protein family A (Hsp70) member 6

Summary

Gene Symbol

HSPA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

3310

PubChem

3310

Alliance of Genome Resources

HGNC:5239

Annotation

Keyword

3D-structure
ATP-binding
Methylation
Reference proteome
Stress response

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P17066	Heat shock 70 kDa protein B' Heat shock protein family A member 6
B3KSM6
A0A384NKX5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
response to unfolded protein	TAS	2327978
cellular response to heat	IDA	24061851
cellular response to heat	IMP	21597468
protein refolding	IDA	21231916
protein refolding	IBA

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

heat acclimation [inference]

cellular heat acclimation

cellular response to heat

cellular heat acclimation

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

response to topologically incorrect protein [inference]

response to unfolded protein

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

heat acclimation [inference]

cellular heat acclimation

cellular response to heat

cellular heat acclimation

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
nucleus	IBA
cytoplasm	IDA	24061851
cytoplasm	IBA
centriole	IDA	24061851

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

centriole

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21044950 32296183
ATP binding	IEA
ATP hydrolysis activity	IDA	21231916
ATP hydrolysis activity	IBA
enzyme binding	IPI	23921388

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heat shock

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Ortholog

Displaying entries **21 - 30** of 32 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Capra hircus	102185412		CAPHI22914
Carlito syrichta	103256412		CARSF20151
Nannospalax galili	103746770		NANGA21031
Rhinopithecus roxellana	104671954		RHIRO45194
Cercocebus atys	105589238		CERAT36933
Propithecus coquereli	105806470		PROCO18148
Microcebus murinus	105873559		MICMU02179
Equus asinus asinus	106831112		EQUAS32394
Xenopus tropicalis	108348108	Xenbase:XB-GENE-485626
Rhinopithecus bieti	108542584		RHIBE36743

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Acknowledgements