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heat shock protein family A (Hsp70) member 9

Summary

Gene Symbol

HSPA9

Organism

Homo sapiens (human)

External Links

NCBI Gene

3313

PubChem

3313

Alliance of Genome Resources

HGNC:5244

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Chaperone
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Dwarfism
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384P5G6	75 kDa glucose-regulated protein Heat shock 70 kDa protein 9
P38646	75 kDa glucose-regulated protein Heat shock 70 kDa protein 9 Heat shock protein family A member 9 Mortalin Peptide-binding protein 74

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein export from nucleus	IEA
intracellular protein transport	NAS	10339406
inner mitochondrial membrane organization	IC	26477565
iron-sulfur cluster assembly	IMP	26702583
iron-sulfur cluster assembly	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

mitochondrial transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

protein transport [inference]

intracellular protein transport

protein export from nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
SAM complex	HDA	26477565
nucleus
nucleolus	IEA
cytoplasm	IBA
mitochondrion	TAS	16130169

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex [inference]

SAM complex

inner mitochondrial membrane protein complex [inference]

mitochondrial protein-containing complex [inference]

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex [inference]

SAM complex

inner mitochondrial membrane protein complex [inference]

cellular anatomical entity [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
protein binding	IPI	10411904 15520177 15657067 17184779 20029029 20153329 20195357 20668094 22340593 22726440 23541579 23940031 24189400 24606901 24625977 25416956 26634371 26702583 27607350 28380382 28514442 30021884 31978385 31980649 32807793 33961781
ATP binding	IEA
ATP hydrolysis activity	IDA	18632665 25615450
ATP hydrolysis activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HSP70

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060335	autosomal dominant sideroblastic anemia 4	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3313	Xenbase:XB-GENE-960228
Mus musculus	15526	Xenbase:XB-GENE-960228	MOUSE23622
Rattus norvegicus	291671		RATNO13680
Danio rerio	373085		DANRE06595
Pan troglodytes	462099		PANTR36277
Canis lupus familiaris	474697		CANLF02157
Bos taurus	517535		BOVIN33528
Macaca mulatta	714506		MACMU39631
Monodelphis domestica	100020208		MONDO05182
Equus caballus	100034032		HORSE08336

GlyTouCan

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LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements