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THO complex 2

Summary

Gene Symbol

Thoc2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

331401

PubChem

331401

Alliance of Genome Resources

MGI:2442413

Annotation

Keyword

Coiled coil
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
mRNA splicing
mRNA transport

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3UUT9
B1AZI6
Q3US09
Q8CCY8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
mRNA export from nucleus	IEA
RNA splicing	IEA
regulation of gene expression	IMP	24315442
regulation of mRNA export from nucleus	IMP	24315442
negative regulation of neuron projection development	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis [inference]

generation of neurons

cell development [inference]

neuron development

cell division [inference]

stem cell division

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

blastocyst development

cell development [inference]

neuron development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis [inference]

generation of neurons

cell development [inference]

neuron development

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of localization [inference]

regulation of transport [inference]

regulation of nucleobase-containing compound transport [inference]

regulation of RNA export from nucleus [inference]

regulation of mRNA export from nucleus

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of RNA export from nucleus [inference]

regulation of mRNA export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of RNA export from nucleus [inference]

regulation of mRNA export from nucleus

regulation of ribonucleoprotein complex localization [inference]

regulation of mRNA export from nucleus

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of RNA export from nucleus [inference]

regulation of mRNA export from nucleus

regulation of ribonucleoprotein complex localization [inference]

regulation of mRNA export from nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transcription export complex	ISO
THO complex	ISO
THO complex	IEA
THO complex part of transcription export complex	ISO
THO complex part of transcription export complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription export complex

THO complex

THO complex part of transcription export complex

cellular anatomical entity [inference]

cytoplasm

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mRNA binding	IMP	24315442
mRNA binding	IBA
protein binding	IPI	24315442

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

THO COMPLEX SUBUNIT 2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mRNA export from nucleus
mRNA processing

Displaying **all 4** entries
InterPro
THO complex subunit 2, N-terminal domain
THO complex subunit 2
THO complex, subunitTHOC2, C-terminal
THO complex, subunitTHOC2, N-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112056	X-linked intellectual disability-short stature-overweight syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	57187	Xenbase:XB-GENE-980539
Rattus norvegicus	313308		RATNO44353
Xenopus tropicalis	331401	Xenbase:XB-GENE-980539
Danio rerio	368417		DANRE06904
Pan troglodytes	465844		PANTR46739
Canis lupus familiaris	481042		CANLF20124
Bos taurus	507738		BOVIN36255
Macaca mulatta	697668		MACMU47902
Xenopus tropicalis	855583	Xenbase:XB-GENE-980539
Monodelphis domestica	100030071		MONDO36109