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heat shock protein family D (Hsp60) member 1

Summary

Gene Symbol

HSPD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3329

PubChem

3329

Alliance of Genome Resources

HGNC:5261

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Chaperone
Direct protein sequencing
Disease variant
Hereditary spastic paraplegia
Host-virus interaction
Isomerase
Isopeptide bond
Leukodystrophy
Mitochondrion
Phosphoprotein
Reference proteome
Stress response
Transit peptide
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P10809	60 kDa chaperonin Chaperonin 60 Heat shock protein 60 Heat shock protein family D member 1 HuCHA60 Mitochondrial matrix protein P1 P60 lymphocyte protein
A0A024R3X4	60 kDa chaperonin Chaperonin 60 Heat shock protein 60

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
MyD88-dependent toll-like receptor signaling pathway	IDA	16148103
positive regulation of T cell mediated immune response to tumor cell	IDA	10663613
protein folding	IBA
'de novo' protein folding	ISS
activation of cysteine-type endopeptidase activity involved in apoptotic process

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

T cell activation

B cell activation

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

T cell activation

B cell activation

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

protein folding

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

B cell proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

apoptotic mitochondrial changes

cellular component assembly [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

T cell activation

B cell activation

B cell activation involved in immune response [inference]

isotype switching [inference]

isotype switching to IgG isotypes

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host

biological process involved in interaction with symbiont

response to stimulus [inference]

response to stress [inference]

response to cold

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

response to interleukin-7 [inference]

cellular response to interleukin-7

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein [inference]

mitochondrial unfolded protein response

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

protein import into mitochondrial intermembrane space

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

organic substance transport [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

nitrogen compound transport [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial intermembrane space

establishment of protein localization to mitochondrion [inference]

protein import into mitochondrial intermembrane space

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of execution phase of apoptosis

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of execution phase of apoptosis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway [inference]

MyD88-dependent toll-like receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of execution phase of apoptosis

negative regulation of apoptotic process

negative regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of execution phase of apoptosis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of execution phase of apoptosis

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of execution phase of apoptosis

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of execution phase of apoptosis [inference]

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

positive regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	18229457
cytoplasm	IDA	21328542
mitochondrion	IDA	17823127 18086682 21245038
mitochondrion	HTP	34800366
mitochondrial inner membrane	ISS

GO Hierarchy

cellular component

protein-containing complex

receptor complex [inference]

lipopolysaccharide receptor complex

membrane protein complex [inference]

lipopolysaccharide receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

sperm plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

plasma membrane region [inference]

clathrin-coated pit

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle

secretory vesicle [inference]

secretory granule

migrasome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle

secretory vesicle [inference]

secretory granule

migrasome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

sperm midpiece

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	IDA	17164250
p53 binding	IPI	18086682
DNA replication origin binding	ISS
single-stranded DNA binding	ISS
RNA binding	HDA	22658674

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity

binding [inference]

protein binding

p53 binding

enzyme binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

apolipoprotein binding

apolipoprotein A-I binding

lipid binding [inference]

lipopolysaccharide binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

high-density lipoprotein particle binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

RNA binding

double-stranded RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity [inference]

cysteine-type endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity [inference]

cysteine-type endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity [inference]

cysteine-type endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity [inference]

cysteine-type endopeptidase activator activity

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Chaperonin

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
mitochondrial unfolded protein response
nucleotide binding
positive regulation of T cell activation
protein refolding
protein-folding chaperone binding
unfolded protein binding

Displaying **all 6** entries
InterPro
Chaperonin Cpn60, conserved site
Chaperonin Cpn60/GroEL/TCP-1 family
Chaperonin Cpn60/GroEL
GroEL-like apical domain superfamily
GroEL-like equatorial domain superfamily
TCP-1-like chaperonin intermediate domain superfamily

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060789	hypomyelinating leukodystrophy 4	Alliance of Genome Resources
DOID:0110766	hereditary spastic paraplegia 13	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3329	Xenbase:XB-GENE-980059
Mus musculus	15510	Xenbase:XB-GENE-980059	MOUSE28238
Rattus norvegicus	63868	Xenbase:XB-GENE-980059	RATNO42628
Danio rerio	282676		DANRE44939
Pan troglodytes	459852		PANTR29436
Canis lupus familiaris	478854		CANLF14086
Bos taurus	511913		BOVIN24502
Monodelphis domestica	100022262		MONDO23439
Monodelphis domestica	100022400		MONDO23439
Monodelphis domestica	100024549		MONDO23439

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements