GlyCosmos Portal

heparan sulfate proteoglycan 2

Summary

Gene Symbol

HSPG2

Aliases

PRCAN
endorepellin
perlecan
perlecan proteoglycan

Organism

Homo sapiens (human)

External Links

NCBI Gene

3339

HGNC

5273

KEGG Gene ID

hsa:3339

PubChem

3339

Alliance of Genome Resources

HGNC:5273

Annotation

Keyword

3D-structure
Angiogenesis
Basement membrane
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Heparan sulfate
Immunoglobulin domain
Laminin EGF-like domain
Metal-binding
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P98160	Perlecan

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
smoothened signaling pathway	IEA
embryo implantation	IEA
animal organ regeneration	IEA
negative regulation of amyloid fibril formation	IGI	21126803
negative regulation of cell adhesion	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell differentiation

reproductive process [inference]

embryo implantation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

system development [inference]

circulatory system development

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

inflammatory response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cell population proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi lumen	TAS
focal adhesion	HDA	21423176
collagen-containing extracellular matrix	HDA	20551380 23658023 23979707 25037231 27559042 28327460 28675934
lysosomal lumen	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11956183 12604605 21596751 23374253
integrin binding		21126803
low-density lipoprotein particle receptor binding	TAS	21289173
collagen V binding	IEA
extracellular matrix structural constituent conferring compression resistance	RCA	20551380 23979707 25037231 27559042 28327460 28675934

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring compression resistance

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

cell adhesion molecule binding [inference]

integrin binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

integrin binding

collagen binding [inference]

collagen V binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K06255

Name

basement membrane-specific heparan sulfate proteoglycan core protein

References

Disease

Disease Ontology

Displaying entries **21 - 30** of **344** in total

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DO ID	Disease Name	Source
DOID:0060277	pontocerebellar hypoplasia type 8	DisGeNET
DOID:0060278	pontocerebellar hypoplasia type 9	DisGeNET
DOID:0060287	cornea plana	DisGeNET
DOID:0060318	acute promyelocytic leukemia	DisGeNET
DOID:0060467	humeroradial synostosis	DisGeNET
DOID:0060469	Miller-Dieker lissencephaly syndrome	DisGeNET
DOID:0060578	Noonan syndrome 1	DisGeNET
DOID:0060580	Noonan syndrome 2	DisGeNET
DOID:0060581	Noonan syndrome 3	DisGeNET
DOID:0060582	Noonan syndrome 4	DisGeNET

The Human Phenotype Ontology

Displaying entries **31 - 40** of **248** in total

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HPO ID	HPO Term
HP:0000347	Micrognathia
HP:0000358	Posteriorly rotated ears
HP:0000368	Low-set, posteriorly rotated ears
HP:0000369	Low-set ears
HP:0000396	Overfolded helix
HP:0000405	Conductive hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000426	Prominent nasal bridge
HP:0000431	Wide nasal bridge
HP:0000457	Depressed nasal ridge

Displaying **all 5** entries
Disease ID	Disease Name
ORPHA:1606	chromosome 1p36 deletion syndrome
OMIM:224410	Silverman-Handmaker type dyssegmental dysplasia
ORPHA:800	Schwartz-Jampel syndrome
OMIM:255800	Schwartz-Jampel syndrome type 1
ORPHA:1865	Silverman-Handmaker type dyssegmental dysplasia

PubChem Disease

GHR Health Conditions

Schwartz-Jampel syndrome

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **41 - 50** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Aotus nancymaae	105708530		AOTNA06271
Propithecus coquereli	105815659		PROCO24009
Dipodomys ordii	105997956		DIPOR06164
Sinocyclocheilus grahami	107568451		SINGR94226
Kryptolebias marmoratus	108237624		KRYMA12539
Xenopus laevis	108696836	Xenbase:XB-GENE-17341349
Cyprinus carpio carpio	109055269		CYPCA128260
Cyprinus carpio carpio	109056836		CYPCA118331
Hippocampus comes	109520187		HIPCM19643
Seriola dumerili	111234870		SERDU15608

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements