N-deacetylase and N-sulfotransferase 1

Summary
Gene Symbol
  • NDST1
Aliases
  • N-Deacetylase-N-sulfotransferase 1
  • NST1
  • [Heparan sulfate]-glucosamine N-sulfotransferase 1
  • heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1
Organism
Homo sapiens (human)
External Links
NCBI Gene
3340
GGDB ID
HGNC
7680
mRNA
map
  • 5q33.1
Protein
OMIM
KEGG Gene ID
hsa:3340
PubChem
3340
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Hydrolase
  • Inflammatory response
  • Intellectual disability
  • Multifunctional enzyme
  • Reference proteome
  • Signal-anchor
  • Transferase
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
A8K8T3
  • Glucosaminyl N-deacetylase/N-sulfotransferase 1
P52848
  • Glucosaminyl N-deacetylase/N-sulfotransferase 1
  • N-heparan sulfate sulfotransferase 1
  • [Heparan sulfate]-glucosamine N-sulfotransferase 1
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000070614

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg020
Gene Symbol
  • NDST1
Orthologous Gene
KEGG BRITE Database
Orthology
K02576
Name
heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.5.1.- 2.8.2.8]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 71 in total
DO ID Disease Name Source
DOID:0050012 chikungunya
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0060041 autism spectrum disorder
DOID:0060810 syndromic X-linked intellectual disability type 10
DOID:0060823 syndromic X-linked intellectual disability 94
DOID:0081210 autosomal recessive intellectual developmental disorder 46
DOID:1059 intellectual disability
DOID:10629 microphthalmia
DOID:10907 microcephaly
DOID:10952 nephritis
The Human Phenotype Ontology
Displaying entries 21 - 28 of 28 in total
HPO ID HPO Term
HP:0002194 Delayed gross motor development
HP:0002360 Sleep abnormality
HP:0002465 Poor speech
HP:0003593 Infantile onset
HP:0004322 Short stature
HP:0010862 Delayed fine motor development
HP:0011463 Childhood onset
HP:0100716 Self-injurious behavior
Displaying 1 entry
Disease ID Disease Name
OMIM:616116
  • intellectual disability, autosomal recessive 46

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024