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Dual oxidase

Summary

Gene Symbol

Duox

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33477

PubChem

33477

Alliance of Genome Resources

FB:FBgn0283531

Annotation

Keyword

Calcium
FAD
Glycoprotein
Heme
Hydrogen peroxide
Metal-binding
NADP
Peroxidase
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M9PCF1
Q9VQH2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
mucosal immune response	IMP	19289084 19668222 25639794
defense response	IBA
response to oxidative stress	IEA
imaginal disc-derived wing morphogenesis	IMP	1039909
adult chitin-based cuticle development	IMP	21808060

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure development [inference]

cuticle development

chitin-based cuticle development [inference]

adult chitin-based cuticle development

animal organ development [inference]

imaginal disc development [inference]

wing disc development

pigmentation [inference]

developmental pigmentation [inference]

cuticle pigmentation [inference]

adult chitin-containing cuticle pigmentation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response

defense response to other organism [inference]

defense response to bacterium

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
endomembrane system	HDA	19317464
NADPH oxidase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

endomembrane system

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
peroxidase activity	IDA	16272120
peroxidase activity	IEA
calcium ion binding	IEA
NAD(P)H oxidase H2O2-forming activity	IMP	34622778
superoxide-generating NAD(P)H oxidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NADPH oxidase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress

Displaying entries **1 - 10** of 12 in total

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InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endomembrane system	PMID:19317464
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050338	primary bacterial infectious disease	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	33477	Xenbase:XB-GENE-6047411
Xenopus tropicalis	50506	Xenbase:XB-GENE-6047411
Xenopus tropicalis	53905	Xenbase:XB-GENE-1005876
Xenopus tropicalis	79107	Xenbase:XB-GENE-6047411
Xenopus tropicalis	99439	Xenbase:XB-GENE-1005876
Xenopus tropicalis	171608	Xenbase:XB-GENE-6047411
Xenopus tropicalis	186188	Xenbase:XB-GENE-6047411
Xenopus tropicalis	266807	Xenbase:XB-GENE-1005876
Xenopus tropicalis	854566	Xenbase:XB-GENE-1005876