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5-hydroxytryptamine receptor 1D

Summary

Gene Symbol

HTR1D

Organism

Homo sapiens (human)

External Links

NCBI Gene

3352

PubChem

3352

Alliance of Genome Resources

HGNC:5289

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P28221	Serotonin 1D alpha receptor Serotonin receptor 1D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
intestine smooth muscle contraction	IMP	9186750
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	1652050
regulation of behavior	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA IDA	33762731

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

intestine smooth muscle contraction

gastro-intestinal system smooth muscle contraction [inference]

intestine smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of locomotion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of behavior

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	1652050
dendrite	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IDA	33762731
serotonin receptor activity	IDA	33762731
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IMP	1652050

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled serotonin receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
chemical synaptic transmission

Displaying **all 3** entries
InterPro
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14320	generalized anxiety disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15552		MGI:96276	MOUSE41113
Rattus norvegicus	25323		RGD:2847	RATNO32334
Drosophila melanogaster	37191		FB:FBgn0263116
Drosophila melanogaster	37196		FB:FBgn0004168
Caenorhabditis elegans	175322		WB:WBGene00004779
Sus scrofa	397309			PIGXX29266
Canis lupus familiaris	403963			CANLF07045
Bos taurus	407136			BOVIN25217
Pan troglodytes	469219	9598_0:000211		PANTR20220
Danio rerio	556429		ZFIN:ZDB-GENE-090409-3	DANRE11913

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OrthoDB (Group)

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Acknowledgements