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5-hydroxytryptamine receptor 4

Summary

Gene Symbol

HTR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3360

PubChem

3360

Alliance of Genome Resources

HGNC:5299

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2D3FAF9	Serotonin receptor 4
Q13639	Serotonin receptor 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
G protein-coupled receptor signaling pathway	TAS	9351641
G protein-coupled serotonin receptor signaling pathway	IEA
regulation of postsynapse assembly	IEA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	9603189

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

intestinal motility [inference]

large intestinal transit

secretion by tissue [inference]

mucus secretion

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

mucus secretion

secretion by tissue [inference]

mucus secretion

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of appetite

regulation of body fluid levels [inference]

body fluid secretion [inference]

mucus secretion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	IDA	16102731
postsynapse	IEA
plasma membrane	IBA IC IDA TAS	10821780 33481771
endosome
dendrite	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28298427
serotonin receptor activity	IDA	33481771
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IDA	10821780 16102731 35714614 9603189

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-Hydroxytryptamine 4 receptor

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
chemical synaptic transmission

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8689	anorexia nervosa	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Octodon degus	101563242		OCTDE08414
Jaculus jaculus	101610259		JACJA16399
Heterocephalus glaber	101707865		HETGA22512
Danio rerio	101882850	ZFIN:ZDB-GENE-160114-31	DANRE07480
Chrysemys picta bellii	101949587		CHRPI02574
Ictidomys tridecemlineatus	101970455		ICTTR07476
Chinchilla lanigera	102004471		CHILA04764
Macaca fascicularis	102142641		MACFA36651
Capra hircus	102178536		CAPHI27201
Pelodiscus sinensis	102450840		PELSI15520

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements