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5-hydroxytryptamine receptor 4

Summary

Gene Symbol

HTR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3360

PubChem

3360

Alliance of Genome Resources

HGNC:5299

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2D3FAF9	Serotonin receptor 4
Q13639	Serotonin receptor 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
chemical synaptic transmission	IBA
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

intestinal motility [inference]

large intestinal transit

secretion by tissue [inference]

mucus secretion

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

mucus secretion

secretion by tissue [inference]

mucus secretion

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of appetite

regulation of body fluid levels [inference]

body fluid secretion [inference]

mucus secretion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	IDA	16102731
postsynapse	IEA
plasma membrane	IBA IC IDA TAS	10821780 33481771
endosome
dendrite	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28298427
serotonin receptor activity	IDA	33481771
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IDA	10821780 16102731 35714614 9603189

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-Hydroxytryptamine 4 receptor

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
chemical synaptic transmission

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8689	anorexia nervosa	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Vicugna pacos	102528004			VICPA03219
Poecilia formosa	103140085			POEFO07746
Chlorocebus sabaeus	103244768			CHLSB11092
Cynoglossus semilaevis	103390655			CYNSE09249
Poecilia reticulata	103471681			POERE02152
Nannospalax galili	103738080			NANGA20157
Esox lucius	105029091			ESOLU10097
Pteropus vampyrus	105299420			PTEVA10018
Macaca nemestrina	105466897			MACNE08096
Mandrillus leucophaeus	105543453			MANLE16434

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Last updated: December 9, 2024