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Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33627

PubChem

33627

Alliance of Genome Resources

FB:FBgn0001075

Annotation

Keyword

Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Mitochondrion
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P33450	Protein fat

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity	IMP	18077345 20826534 22399682 22499807 27746048
establishment of planar polarity	IGI	20826534
establishment of imaginal disc-derived wing hair orientation	IMP	16687445 16735478 20817616 21379328
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI	15240556

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule cytoskeleton organization involved in establishment of planar polarity

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

establishment or maintenance of cell polarity [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule cytoskeleton organization involved in establishment of planar polarity

multicellular organismal process [inference]

multicellular organism development [inference]

instar larval or pupal development [inference]

pupal development

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation

post-embryonic development [inference]

instar larval or pupal development [inference]

pupal development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity

establishment of planar polarity

establishment of body hair or bristle planar orientation [inference]

establishment of body hair planar orientation

post-embryonic animal morphogenesis [inference]

establishment of imaginal disc-derived wing hair orientation

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of anatomical boundary [inference]

equator specification

anatomical structure development [inference]

multicellular organism development [inference]

instar larval or pupal development [inference]

pupal development

tissue development

animal organ development [inference]

imaginal disc development [inference]

wing disc development

growth [inference]

developmental growth [inference]

imaginal disc growth

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of growth

negative regulation of growth

negative regulation of developmental growth [inference]

regulation of developmental growth [inference]

regulation of imaginal disc growth

negative regulation of imaginal disc growth

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of growth

negative regulation of developmental growth [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity

regulation of developmental growth [inference]

regulation of imaginal disc growth

negative regulation of imaginal disc growth

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular localization [inference]

regulation of protein localization

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion
plasma membrane	IDA	15240556
plasma membrane	IEA
apical plasma membrane
apicolateral plasma membrane	IDA	27746048

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	IDA	15240556
calcium ion binding	IEA
protein binding	IPI	20434335 27746048
cadherin binding	IPI	15240556

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 7** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like domain
Laminin G domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
apicolateral plasma membrane	PMID:27746048
plasma membrane	PMID:15240556

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080586	Van Maldergem syndrome 2	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:305	carcinoma	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	33627	Xenbase:XB-GENE-981052
Xenopus tropicalis	79633	Xenbase:XB-GENE-981052
Xenopus tropicalis	329628	Xenbase:XB-GENE-981052

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements