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Guidelines

MIRAGE

nicalin

Summary

Gene Symbol

ncln

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

336844

PubChem

336844

Alliance of Genome Resources

ZFIN:ZDB-GENE-030131-8788

Annotation

Keyword

Alternative splicing
Developmental protein
Endoplasmic reticulum
Glycoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8M2B8R6
A0A8M2B8L1
Q6NZ07	Nicalin-1 Nicastrin-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
determination of left/right asymmetry in lateral mesoderm	IMP	15257293
regulation of signal transduction	IDA	15257293
regulation of signal transduction	IMP	15257293
regulation of signal transduction	IBA
regulation of signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry [inference]

determination of left/right asymmetry in lateral mesoderm

developmental process [inference]

anatomical structure development [inference]

system development [inference]

enteric nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

multi-pass transmembrane protein insertion into ER membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

regulation of nodal signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway [inference]

negative regulation of nodal signaling pathway

Displaying entries **1 - 5** of 6 in total

1

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	IDA	15257293
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

ER membrane insertion complex [inference]

multi-pass translocon complex

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
ribosome binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nicalin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 2** entries
InterPro
Nicalin
Peptidase M28

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026