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cholinergic receptor nicotinic alpha 1 subunit

Summary

Gene Symbol

CHRNA1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 338070
PubChem: 338070

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P02709

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
skeletal muscle contraction
signal transduction	IEA	30032202
chemical synaptic transmission	IEA	30032202
synaptic transmission, cholinergic
neuromuscular synaptic transmission

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

skeletal muscle contraction

nervous system process

growth [inference]

developmental growth [inference]

skeletal muscle tissue growth

homeostatic process [inference]

cellular homeostasis [inference]

response to stimulus [inference]

response to chemical [inference]

response to nicotine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

membrane depolarization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
acetylcholine-gated channel complex
cell surface
neuromuscular junction
neuron projection	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

acetylcholine-gated channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

acetylcholine-gated channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA	22301074 30032202
acetylcholine receptor activity
acetylcholine-gated monoatomic cation-selective channel activity	IEA	22301074
acetylcholine binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

binding [inference]

ion binding [inference]

cation binding [inference]

acetylcholine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

acetylcholine receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acetylcholine receptor subunit

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
excitatory extracellular ligand-gated monoatomic ion channel activity
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
regulation of postsynaptic membrane potential
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Nicotinic acetylcholine receptor

Ortholog

Displaying entries **1 - 10** of **100** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1134	HUMAN65639
Mus musculus	11435	MOUSE32847
Danio rerio	30725	DANRE37848
Rattus norvegicus	79557	RATNO28184
Sus scrofa	396587	PIGXX09520
Canis lupus familiaris	403757	CANLF13981
Takifugu rubripes	446014	TAKRU24042
Takifugu rubripes	446087	TAKRU40388
Pan troglodytes	470583	PANTR29179
Macaca mulatta	698578	MACMU05743