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glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Summary

Gene Symbol

GPIHBP1

Aliases

GPI-HBP1
LOC338328
endothelial cell LPL transporter

Organism

Homo sapiens (human)

External Links

NCBI Gene

338328

HGNC

24945

KEGG Gene ID

hsa:338328

PubChem

338328

Alliance of Genome Resources

HGNC:24945

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
GPI-anchor
Lipid-binding
Reference proteome
Signal
Sulfation
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IV16	High density lipoprotein-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
triglyceride catabolic process	IDA	30559189
positive regulation of chylomicron remnant clearance	ISS
positive regulation of lipoprotein lipase activity	IBA IDA IMP	20124439 29899144
triglyceride homeostasis	IBA IMP NAS	20124439 30559189
cholesterol homeostasis	ISS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

transcytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

multicellular organismal process [inference]

transcytosis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to heparin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to heparin

response to oxygen-containing compound [inference]

response to heparin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

establishment of protein localization [inference]

protein transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

regulation of chylomicron remnant clearance [inference]

positive regulation of chylomicron remnant clearance

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

positive regulation of lipoprotein lipase activity

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region
external side of plasma membrane	IDA	17997385 20124439
plasma membrane	IBA TAS
catalytic complex	IPI	30559189
apical plasma membrane	ISS	20620994

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

plasma membrane region [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
lipoprotein particle binding	IDA	17997385
lipase binding	IBA IPI	20124439 29899144
lipid binding	IEA
chylomicron binding	IBA IDA	19304573
acetylcholine receptor inhibitor activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

enzyme binding [inference]

lipase binding

lipid binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

chylomicron binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

lipoprotein lipase activator activity

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity [inference]

acetylcholine receptor inhibitor activity

neurotransmitter receptor regulator activity [inference]

acetylcholine receptor regulator activity [inference]

acetylcholine receptor inhibitor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

lipoprotein lipase activator activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

acetylcholine receptor inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K20001

Name

glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

References

21844202

Disease

Disease Ontology

Displaying entries **1 - 10** of 28 in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0111420	familial GPIHBP1 deficiency	DisGeNET Alliance of Genome Resources
DOID:114	heart disease	DisGeNET
DOID:1168	familial hyperlipidemia	DisGeNET DisGeNET
DOID:1171	hyperlipoproteinemia type V	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000660	Lipemia retinalis
HP:0001013	Eruptive xanthomas
HP:0001508	Failure to thrive
HP:0001733	Pancreatitis
HP:0001744	Splenomegaly
HP:0002155	Hypertriglyceridemia
HP:0002240	Hepatomegaly
HP:0002583	Colitis
HP:0003233	Decreased HDL cholesterol concentration

Displaying 1 entry
Disease ID	Disease Name
OMIM:615947	hyperlipoproteinemia, type 1D

PubChem Disease

MedGen Diseases

Hyperlipoproteinemia, type 1D

OMIM Phenotypes

HYPERLIPOPROTEINEMIA, TYPE ID

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003729
Gene Name: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100414227	CALJA13568
Cercocebus atys	105581295	CERAT34216
Macaca mulatta	696277	MACMU43876
Papio anubis	101007942	PAPAN39714
Mandrillus leucophaeus	105536292	MANLE24486
Gorilla gorilla gorilla	129524076	GORGO40686
Pan paniscus	100980066	PANPA39001
Pan troglodytes	739257	PANTR43384
Pongo abelii	103891410	PONAB35009
Canis lupus familiaris	609267	CANLF03267

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements