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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Summary

Gene Symbol

ST8SIA6

Aliases

ST8Sia VI

Organism

Homo sapiens (human)

External Links

NCBI Gene

338596

GGDB ID

gg067

HGNC

23317

mRNA

NM_001004470

map

10p12.33

Protein

NP_001004470

OMIM

610139

KEGG Gene ID

hsa:338596

PubChem

338596

Alliance of Genome Resources

HGNC:23317

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P61647	Sialyltransferase 8F Sialyltransferase St8Sia VI

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein O-linked glycosylation	ISS	11980897
N-glycan processing	IBA
blastocyst hatching	IEA
oligosaccharide metabolic process	IBA ISS	11980897
glycolipid biosynthetic process	ISS	11980897

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

N-glycan processing

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

N-glycan processing

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

N-glycan processing

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

N-glycan processing

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

multicellular organismal process [inference]

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA TAS
sialyltransferase activity	ISS	11980897

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg067

Gene Symbol

ST8SIA6

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G91237TK	G98544DH	11980897
CMP-Neu5Ac	G73578JC	G94903EJ	11980897

Displaying entries **1 - 10** of 14 in total

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Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G01767JJ	G70647TI	11980897
CMP-Neu5Ac	G28868ZC	G34177WW	11980897
CMP-Neu5Ac	G83513YI	G31627XJ	11980897
CMP-Neu5Ac	G00065MO	G94903EJ	11980897
CMP-Neu5Ac	G36123IU	G25604VV	16120058
CMP-Neu5Ac	G40183QN	G18625KA	11980897 16120058
CMP-Neu5Ac	G01854WM	G97551IW	11980897
CMP-Neu5Ac	G91237TK	G98544DH	11980897
CMP-Neu5Ac	G03277YI	G81983KG	11980897
CMP-Neu5Ac	G73578JC	G94903EJ	11980897

Displaying entries **1 - 10** of 12 in total

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Donor	Acceptor	Reference
CMP-Neu5Ac	G50850NI	11980897
CMP-Neu5Ac	G18625KA	11980897
CMP-Neu5Ac	G65889KE	11980897
CMP-Neu5Ac	G84224TW	11980897
CMP-Neu5Ac	G48558GR	11980897
CMP-Neu5Ac	G98544DH	11980897 16120058
CMP-Neu5Ac	G01534TU	16120058
CMP-Neu5Ac	G68639CF	16120058
CMP-Neu5Ac	G57321FI	11980897
CMP-Neu5Ac	G37184KW	11980897 16120058

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Mus musculus	NP_665837	NM_145838

KEGG BRITE Database

Orthology

K06615

Name

alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8F) [EC:2.4.3.-]

References

11980897

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080147	lymphoblastic lymphoma	DisGeNET
DOID:9952	acute lymphoblastic leukemia	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP004919
Gene Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Ortholog

Displaying entries **11 - 20** of 46 in total

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Species	Gene ID	Orthologous MAtrix
Crocodylus porosus	109308212	CROPO01432
Callithrix jacchus	100398727	CALJA39991
Cercocebus atys	105583834	CERAT18538
Macaca fascicularis	102123210	MACFA42075
Macaca nemestrina	105488224	MACNE33402
Papio anubis	101009332	PAPAN03645
Gorilla gorilla gorilla	101139610	GORGO00675
Pan troglodytes	450329	PANTR00248
Pongo abelii	100445866	PONAB00843
Ailuropoda melanoleuca	100465404	AILME13377

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements