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MIRAGE
complement factor I
Summary
- Gene Symbol
-
- CFI
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Calcium
- Cleavage on pair of basic residues
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Hemolytic uremic syndrome
- Host-virus interaction
- Metal-binding
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| complement activation, classical pathway | ||
| innate immune response |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| membrane | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| serine-type endopeptidase activity | ||
| protein binding | ||
| serine-type peptidase activity |
|
|
| metal ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- DNA primase
- Functional Category
-
- K: Transcription
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| DNA replication, synthesis of RNA primer |
| metal ion binding |
| nucleotidyltransferase activity |
| transferase activity |
| InterPro |
|---|
| DNA primase, small subunit, eukaryotic/archaeal |
| DNA primase, small subunit |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050419 | complement factor I deficiency | |
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:0110025 | age related macular degeneration 13 | |
| DOID:10873 | Kuhnt-Junius degeneration | |
| DOID:4448 | macular degeneration |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3426 | Xenbase:XB-GENE-5953276 | ||
| 12630 | Xenbase:XB-GENE-5953276 | MOUSE37512 | |
| 79126 | Xenbase:XB-GENE-5953276 | RATNO24437 | |
| 471271 | PANTR34318 | ||
| 478514 | CANLF13150 | ||
| 478515 | CANLF13150 | ||
| 513197 | BOVIN31070 | ||
| 720962 | MACMU37286 | ||
| 100010034 | MONDO27981 | ||
| 100072852 | HORSE27190 |
