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aquaporin 8

Summary

Gene Symbol

AQP8

Organism

Homo sapiens (human)

External Links

NCBI Gene

343

PubChem

343

Alliance of Genome Resources

HGNC:642

Annotation

Keyword

Cell membrane
Endoplasmic reticulum
Glycoprotein
Mitochondrion inner membrane
Oxidation
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O94778

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
methylammonium transmembrane transport	IEA
ammonium transmembrane transport	IMP ISS	22622463
regulation of cholesterol biosynthetic process	IMP	30579780
urea transmembrane transport	IEA
cellular response to cAMP	IEP	17636236

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

ammonium transmembrane transport

ammonium import across plasma membrane

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

cellular detoxification

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

cellular response to cAMP

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport [inference]

water transport

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

ammonium transmembrane transport

ammonium import across plasma membrane

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport

transepithelial water transport

organic cation transport [inference]

methylammonium transport

methylammonium transmembrane transport

amine transport [inference]

methylammonium transport

methylammonium transmembrane transport

one-carbon compound transport [inference]

urea transport

urea transmembrane transport

methylammonium transport

methylammonium transmembrane transport

hydrogen peroxide transmembrane transport

nitrogen compound transport [inference]

amine transport [inference]

methylammonium transport

methylammonium transmembrane transport

amide transport [inference]

urea transport

urea transmembrane transport

ammonium transmembrane transport

ammonium import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

detoxification [inference]

cellular detoxification

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mitochondrial membrane	ISS
apical plasma membrane	ISS
mitochondrial inner membrane	IDA ISS	22622463 34292591
plasma membrane	IBA ISS TAS
smooth endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053
methylammonium channel activity	IDA	15948717
urea channel activity	ISS
ammonium transmembrane transporter activity	ISS
water channel activity	IBA IDA IMP ISS	15948717 18948439

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

organic cation transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

inorganic cation transmembrane transporter activity [inference]

ammonium transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

amide transmembrane transporter activity [inference]

urea transmembrane transporter activity [inference]

urea channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2316	brain ischemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11833	MGI:1195271	MOUSE56910
Rattus norvegicus	29172	RGD:2146	RATNO20928
Drosophila melanogaster	37737	FB:FBgn0034883
Drosophila melanogaster	37738	FB:FBgn0034884
Drosophila melanogaster	37739	FB:FBgn0034885
Caenorhabditis elegans	179366	WB:WBGene00000172
Caenorhabditis elegans	183121	WB:WBGene00000174
Caenorhabditis elegans	183221	WB:WBGene00000173
Ovis aries	443183		SHEEP12360
Danio rerio	447923	ZFIN:ZDB-GENE-040912-106