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Guidelines

MIRAGE

aquaporin 8

Summary

Gene Symbol

AQP8

Organism

Homo sapiens (human)

External Links

NCBI Gene

343

PubChem

343

Alliance of Genome Resources

HGNC:642

Annotation

Keyword

Cell membrane
Endoplasmic reticulum
Glycoprotein
Mitochondrion inner membrane
Oxidation
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O94778

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
water transport	ISS
water transport	IDA	15948717
water transport	IBA
urea transport	ISS
methylammonium transport	IDA	15948717

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

ammonium transmembrane transport

ammonium import across plasma membrane

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

cellular detoxification

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

cellular response to cAMP

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport [inference]

water transport

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

ammonium transmembrane transport

ammonium import across plasma membrane

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport

transepithelial water transport

organic cation transport [inference]

methylammonium transport

methylammonium transmembrane transport

amine transport [inference]

methylammonium transport

methylammonium transmembrane transport

one-carbon compound transport [inference]

urea transmembrane transport

methylammonium transport

methylammonium transmembrane transport

hydrogen peroxide transmembrane transport

nitrogen compound transport [inference]

amine transport [inference]

methylammonium transport

methylammonium transmembrane transport

amide transport [inference]

urea transmembrane transport

ammonium transmembrane transport

ammonium import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

detoxification [inference]

cellular detoxification

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISS
mitochondrial inner membrane	ISS
mitochondrial inner membrane	IDA	22622463 34292591
smooth endoplasmic reticulum	ISS
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053
ammonium transmembrane transporter activity	ISS
water channel activity	ISS
water channel activity	IDA	15948717
water channel activity	IMP	18948439

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

organic cation transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

inorganic cation transmembrane transporter activity [inference]

ammonium transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

amide transmembrane transporter activity [inference]

urea transmembrane transporter activity [inference]

urea channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aquaporin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin 8
Aquaporin transporter
Aquaporin-like
Major intrinsic protein

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	343	Xenbase:XB-GENE-481926
Drosophila melanogaster	11827	FB:FBgn0034884
Drosophila melanogaster	11831	FB:FBgn0034884
Mus musculus	11833	Xenbase:XB-GENE-481926	MOUSE56910
Rattus norvegicus	29172	Xenbase:XB-GENE-481926	RATNO20928
Ovis aries	443183		SHEEP12360
Bos taurus	450206		BOVIN20488
Pan troglodytes	468096		PANTR12003
Canis lupus familiaris	608036		CANLF16461
Macaca mulatta	702167		MACMU27114

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025