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monoacylglycerol O-acyltransferase 3

Summary

Gene Symbol

MOGAT3

Aliases

DC7
DGAT2L2
MGAT3

Organism

Homo sapiens (human)

External Links

NCBI Gene

346606

HGNC

23249

KEGG Gene ID

hsa:346606

PubChem

346606

Alliance of Genome Resources

HGNC:23249

Annotation

Keyword

Acyltransferase
Alternative splicing
Cytoplasm
Endoplasmic reticulum
Glycerol metabolism
Glycoprotein
Lipid biosynthesis
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86VF5	Acyl-CoA:monoacylglycerol acyltransferase 3 Diacylglycerol O-acyltransferase candidate 7 Diacylglycerol acyltransferase 2-like protein 7 Monoacylglycerol O-acyltransferase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
monoacylglycerol biosynthetic process	IDA	28420705
triglyceride biosynthetic process	IBA IDA IEA TAS	27184406
glycerol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IDA TAS	27184406
perinuclear endoplasmic reticulum membrane	IDA	27184406

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
diacylglycerol O-acyltransferase activity	IBA IDA	27184406
2-acylglycerol O-acyltransferase activity	IDA TAS	27184406

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000106384

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K14456

Name

2-acylglycerol O-acyltransferase 3 [EC:2.3.1.20 2.3.1.22]

References

Rhea

RHEA:10868

a 1,2-diacyl-sn-glycerol + an acyl-CoA

CoA + a triacyl-sn-glycerol

Enzyme

2.3.1.20

PMID

RHEA:16741

a 2-acylglycerol + an acyl-CoA

a 1,2-diacylglycerol + CoA

Enzyme

2.3.1.22

PMID

12621063

Disease

Disease Ontology

Displaying entries **11 - 17** of 17 in total

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DO ID	Disease Name	Source
DOID:0110047	Alzheimer's disease 14	DisGeNET
DOID:0110048	Alzheimer's disease 15	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET
DOID:11870	Pick's disease	DisGeNET
DOID:1443	cerebral degeneration	DisGeNET
DOID:14525	Reye syndrome	DisGeNET
DOID:9452	steatotic liver disease	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006720
Gene Name: monoacylglycerol O-acyltransferase 3

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175417	WB:WBGene00021818
Caenorhabditis elegans	179314	WB:WBGene00019464
Caenorhabditis elegans	180160	WB:WBGene00010296
Caenorhabditis elegans	189077	WB:WBGene00020910
Drosophila melanogaster	35718	FB:FBgn0033214
Drosophila melanogaster	35719	FB:FBgn0033215
Latimeria chalumnae	102359647		LATCH03831
Danio rerio	494083	ZFIN:ZDB-GENE-110302-2
Danio rerio	100142647	ZFIN:ZDB-GENE-080305-11
Xenopus laevis	108710383	Xenbase:XB-GENE-17346062