GlyCosmos Portal

Annotation

Keyword

Calcium
Endoplasmic reticulum
Glycosidase
Metal-binding
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9VK27
M9PCV1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
ERAD pathway	IGI	19805114
carbohydrate metabolic process	IEA
response to endoplasmic reticulum stress	IEP	25716426
mannose trimming involved in glycoprotein ERAD pathway	IBA
endoplasmic reticulum mannose trimming	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to oxygen-containing compound [inference]

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	25716426
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA IEA ISM	19805114
calcium ion binding	IEA
unfolded protein binding	IPI	19805114

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

protein binding [inference]

unfolded protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	FB:FBrf0231198
endoplasmic reticulum	PMID:25716426

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050571	congenital disorder of glycosylation type II	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	181210	WB:WBGene00013919
Danio rerio	559811	ZFIN:ZDB-GENE-070801-5
Danio rerio	562939	ZFIN:ZDB-GENE-091113-49
Xenopus tropicalis	100145667	Xenbase:XB-GENE-5811499
Homo sapiens	80267	HGNC:16787
Mus musculus	66967	MGI:1914217
Rattus norvegicus	289085	RGD:1561496
Saccharomyces cerevisiae S288C	856611	SGD:S000001247

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

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International Collaboration

Acknowledgements