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Angiotensin converting enzyme

Summary

Gene Symbol

Ance

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34805

PubChem

34805

Alliance of Genome Resources

FB:FBgn0012037

Annotation

Keyword

3D-structure
Carboxypeptidase
Coiled coil
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q10714	Dipeptidyl carboxypeptidase I Kininase II
X2J8C3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sexual reproduction	IEP	17921161
proteolysis	IDA IEA	12431739 12431741 16403023 17921161 23082758 7775412 8761461 9461491 9839949
response to symbiotic bacterium	IEP	18171476
metamorphosis	IEP	12093364
peptide hormone processing	IDA	12431739 9461491 9839949

GO Hierarchy

biological process

reproduction [inference]

sexual reproduction

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

multicellular organismal process [inference]

multicellular organism development [inference]

metamorphosis

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

metamorphosis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
plasma membrane	IBA
extracellular space	IBA IDA	12431741 17921161 7775412 9839949

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidyl-dipeptidase activity	IDA IEA	10913309 12431739 12431741 16403023 17921161 23082758 7775412 8761461 9461491 9839949
metal ion binding
metallopeptidase activity	IBA IDA IEA	12633854
carboxypeptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

exopeptidase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
extracellular space	PMID:12431741 PMID:17921161 PMID:7775412 PMID:9839949
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying entries **61 - 70** of 81 in total

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DO ID	Disease Name	Source
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:61	mitral valve disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:7147	ankylosing spondylitis	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:790	ocular hypotension	Alliance of Genome Resources
DOID:820	myocarditis	Alliance of Genome Resources
DOID:841	extrinsic allergic alveolitis	Alliance of Genome Resources
DOID:8432	polycythemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	1636		HGNC:2707
Mus musculus	11421		MGI:87874
Rattus norvegicus	24310		RGD:2493
Caenorhabditis elegans	180780		WB:WBGene00000039
Mus musculus	217246		MGI:3644400
Danio rerio	492331		ZFIN:ZDB-GENE-041114-6
Rattus norvegicus	498012		RGD:1561299
Danio rerio	565980		ZFIN:ZDB-GENE-030131-1826
Drosophila ananassae	6497096	7217_1:002eff
Drosophila yakuba	6527571	7245_1:000951

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements