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insulin like growth factor 2 receptor

Summary

Gene Symbol

IGF2R

Aliases

CD222
CI-M6PR
CI-MPR
CIMPR
M6P-R
MPR1
MPR300
MPRI
cation-independent mannose-6 phosphate receptor

Organism

Homo sapiens (human)

External Links

NCBI Gene

3482

HGNC

5467

KEGG Gene ID

hsa:3482

PubChem

3482

Alliance of Genome Resources

HGNC:5467

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Methylation
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
P11717	300 kDa mannose 6-phosphate receptor Insulin-like growth factor 2 receptor Insulin-like growth factor II receptor M6P/IGF2 receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
animal organ regeneration	IEA
G protein-coupled receptor signaling pathway	IEA
response to tetrachloromethane	IEA
spermatogenesis	IEA
response to retinoic acid	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

gland development [inference]

liver development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to tetrachloromethane

response to oxygen-containing compound [inference]

response to retinoic acid

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

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GO Term	Evidence Code	PMID
clathrin-coated endocytic vesicle membrane
endosome	IDA	15078902
transport vesicle
trans-Golgi network	IBA IMP	17959629
endocytic vesicle	IDA	10900005

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
enzyme binding	IEA
retromer complex binding	IDA	18817523
mannose binding	IEA
G-protein alpha-subunit binding	IEA
signaling receptor activity		7753549

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

binding [inference]

protein binding

G-protein alpha-subunit binding

growth factor binding [inference]

insulin-like growth factor binding

insulin-like growth factor II binding

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

carbohydrate binding [inference]

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

monosaccharide binding [inference]

mannose binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

protein-containing complex binding [inference]

retromer complex binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000197081

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06564

Name

insulin-like growth factor 2 receptor

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:277	chorioangioma	DisGeNET
DOID:0050463	campomelic dysplasia	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050879	fragile X-associated tremor/ataxia syndrome	DisGeNET
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060476	Perlman syndrome	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET

The Human Phenotype Ontology

Displaying **all 4** entries
HPO ID	HPO Term
HP:0001402	Hepatocellular carcinoma
HP:0001413	Micronodular cirrhosis
HP:0001442	Typified by somatic mosaicism
HP:0006572	Subacute progressive viral hepatitis

Displaying 1 entry
Disease ID	Disease Name
OMIM:114550	hepatocellular carcinoma

PubChem Disease

MedGen Diseases

Hepatocellular carcinoma

OMIM Phenotypes

HEPATOCELLULAR CARCINOMA

KEGG Diseases

Hepatocellular carcinoma

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43223	FB:FBgn0051072
Danio rerio	557061	ZFIN:ZDB-GENE-041014-300	DANRE18855
Astyanax mexicanus	103037532		ASTMX01193
Ictalurus punctatus	100304998		ICTPU19974
Electrophorus electricus	113570044		ELEEL06117
Salmo salar	106571395		SALSA39657
Salmo salar	106607799		SALSA131133
Salmo trutta	115174818		SALTR52858
Salmo trutta	115192936		SALTR25112
Gadus morhua	115534230		GADMO33576

GlyTouCan

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GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements