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insulin like growth factor 2 receptor

Summary

Gene Symbol

IGF2R

Aliases

CD222
CI-M6PR
CI-MPR
CIMPR
M6P-R
MPR1
MPR300
MPRI
cation-independent mannose-6 phosphate receptor

Organism

Homo sapiens (human)

External Links

NCBI Gene

3482

HGNC

5467

KEGG Gene ID

hsa:3482

PubChem

3482

Alliance of Genome Resources

HGNC:5467

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Methylation
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
P11717	300 kDa mannose 6-phosphate receptor Insulin-like growth factor 2 receptor Insulin-like growth factor II receptor M6P/IGF2 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
liver development	IEA
receptor-mediated endocytosis	TAS	10799489
lysosomal transport	IBA
signal transduction	TAS	7753549
G protein-coupled receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

gland development [inference]

liver development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to tetrachloromethane

response to oxygen-containing compound [inference]

response to retinoic acid

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
nuclear envelope lumen	IEA
endosome	IDA	15078902
early endosome	IMP	17959629
late endosome	IDA	22456507

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
G-protein alpha-subunit binding	IEA
retinoic acid binding	IEA
insulin-like growth factor receptor activity	TAS	10799489
protein binding	IDA	10900005
protein binding	IPI	10900005 11387475 11390366 16977309 17850746 18046459 37100772 37219487

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

binding [inference]

protein binding

G-protein alpha-subunit binding

growth factor binding [inference]

insulin-like growth factor binding

insulin-like growth factor II binding

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

carbohydrate binding [inference]

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

monosaccharide binding [inference]

mannose binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

protein-containing complex binding [inference]

retromer complex binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin-like growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cation-independent mannose-6-phosphate receptor

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MRH domain
Mannose-6-phosphate receptor binding domain superfamily
Mannose-6-phosphate receptor

Human Protein Atlas

ENSG00000197081

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06564

Name

insulin-like growth factor 2 receptor

References

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:2154	nephroblastoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:8719	in situ carcinoma	Alliance of Genome Resources
DOID:8791	breast carcinoma in situ	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 4** entries
HPO ID	HPO Term
HP:0001402	Hepatocellular carcinoma
HP:0001413	Micronodular cirrhosis
HP:0001442	Typified by somatic mosaicism
HP:0006572	Subacute progressive viral hepatitis

Displaying 1 entry
Disease ID	Disease Name
OMIM:114550	hepatocellular carcinoma

PubChem Disease

MedGen Diseases

Hepatocellular carcinoma

OMIM Phenotypes

HEPATOCELLULAR CARCINOMA

KEGG Diseases

Hepatocellular carcinoma

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3482	Xenbase:XB-GENE-480957
Mus musculus	16004	Xenbase:XB-GENE-480957	MOUSE21274
Rattus norvegicus	25151		RATNO19274
Xenopus tropicalis	43223	Xenbase:XB-GENE-480957
Bos taurus	281849		BOVIN36075
Sus scrofa	397214		PIGXX13132
Ovis aries	443500		SHEEP18946
Pan troglodytes	463112		PANTR39434
Canis lupus familiaris	484067		CANLF00254
Danio rerio	557061		DANRE18855

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements