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Guidelines

MIRAGE

14-alpha sterol demethylase Cyp51A

Summary

Gene Symbol

AFUA_4G06890

Organism

Aspergillus fumigatus Af293

External Links

NCBI Gene: 3509526
PubChem: 3509526

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Heme
Methyltransferase
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4WNT5	Cytochrome P450 monooxygenase 51A Ergosterol biosynthesis protein 11A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ergosterol biosynthetic process	IEA	30032202
methylation

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

methylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

secondary alcohol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

secondary alcohol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
monooxygenase activity	IEA	22301074
iron ion binding	IEA	22301074
methyltransferase activity
sterol 14-demethylase activity
oxidoreductase activity

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

sterol 14-demethylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

sterol 14-demethylase activity

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

demethylase activity [inference]

sterol 14-demethylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group IV
Cytochrome P450, conserved site
Cytochrome P450

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026