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HMG-CoA reductase

Summary

Gene Symbol

AFUA_1G11230

Organism

Aspergillus fumigatus Af293

External Links

NCBI Gene: 3510314
PubChem: 3510314

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
NADP
Oxidoreductase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4WSY2	Ergosterol biosynthesis protein hmg2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
coenzyme A metabolic process	IEA	22301074 30032202
ergosterol biosynthetic process	IEA	30032202
isoprenoid biosynthetic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

secondary alcohol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

secondary alcohol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

ergosterol metabolic process [inference]

ergosterol biosynthetic process

cellular lipid biosynthetic process [inference]

ergosterol biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202
peroxisomal membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hydroxymethylglutaryl-CoA reductase (NADPH) activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ergosterol biosynthetic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 8** entries
InterPro
Hydroxymethylglutaryl-CoA reductase, N-terminal
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II
Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
Sterol-sensing domain

Ortholog

Displaying **all 5** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Aspergillus fischeri NRRL 181	4591133	331117_0:001c83
Aspergillus novofumigatus IBT 16806	36538526	1392255_0:001c01
Aspergillus thermomutatus	38125037	41047_0:0011d3
Aspergillus viridinutans	66934929	75553_0:001048
Aspergillus pseudoviridinutans	67001351	1517512_0:000912

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Last updated: December 9, 2024