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GALAXY
MCAW
GlycoSim
GRable
Guidelines
MIRAGE
amyloid beta precursor protein
Summary
- Gene Symbol
-
- APP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloid
- Amyloidosis
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Coiled coil
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Neurodegeneration
- Notch signaling pathway
- Nucleus
- Oxidation
- Phosphoprotein
- Protease
- Proteoglycan
- Proteomics identification
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| B4DGD0 |
|
| A0A0A0MRG2 |
|
| E9PG40 |
|
| P05067 |
|
| A0A140VJC8 |
|
| B4DJT9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| G2/M transition of mitotic cell cycle | ||
| negative regulation of transcription by RNA polymerase II | ||
| microglial cell activation | ||
| microglial cell activation | ||
| response to yeast |
GO Hierarchy
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cell activation
- positive regulation of response to endoplasmic reticulum stress
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of response to endoplasmic reticulum stress
- negative regulation of long-term synaptic potentiation
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of response to endoplasmic reticulum stress
- regulation of response to calcium ion
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of nitric oxide biosynthetic process
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cell activation
- positive regulation of response to endoplasmic reticulum stress
- regulation of multicellular organism growth
- regulation of amyloid-beta clearance
biological process
metabolic process [inference]
cellular process [inference]
homeostatic process [inference]
biological process involved in interspecies interaction between organisms [inference]
response to stimulus [inference]
response to stress [inference]
response to external stimulus [inference]
response to biotic stimulus [inference]
response to chemical [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of protein metabolic process
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cellular catabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of protein metabolic process
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of protein metabolic process
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cellular catabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of cellular localization [inference]
regulation of cellular response to stress [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| extracellular space | ||
| nucleus |
GO Hierarchy
cellular component
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| G protein-coupled receptor binding | ||
| DNA binding | ||
| chromatin binding | ||
| serine-type endopeptidase inhibitor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- amyloid beta precursor protein
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| central nervous system development |
| heparin binding |
| metal ion binding |
| serine-type endopeptidase inhibitor activity |
| transition metal ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070028 | APP-related cerebral amyloid angiopathy | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0081292 | traumatic brain injury | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1561 | cognitive disorder |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 115541382 | GADMO45767 | ||
| 115576736 | SPAAU65995 | ||
| 116438635 | CORMO14410 | ||
| 117034292 | RHIFE06199 | ||
| 118300896 | SCOMX15141 | ||
| 118894510 | BALMU18515 | ||
| 122198638 | PANLE24654 | ||
| 123784172 | URSAM04058 |
