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peptidyl arginine deiminase 6

Summary

Gene Symbol

PADI6

Organism

Homo sapiens (human)

External Links

NCBI Gene

353238

HGNC

20449

PubChem

353238

Alliance of Genome Resources

HGNC:20449

JoGo

PADI6

TogoVar

PADI6

Annotation

Keyword

3D-structure
Cytoplasm
Cytoplasmic vesicle
Disease variant
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6TGC4	Peptidyl arginine deiminase-like protein Peptidylarginine deiminase VI Protein-arginine deiminase type VI Protein-arginine deiminase type-6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
in utero embryonic development	IEA
cytoskeleton organization	IEA
cytoplasm organization	IEA
embryonic cleavage	ISS
regulation of translation by machinery localization	IEA

GO Hierarchy

biological process

cellular process [inference]

cell division [inference]

embryonic cleavage

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

regulation of translation by machinery localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cytoplasm organization

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

regulation of translation by machinery localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

regulation of translation by machinery localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translation by machinery localization

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translation by machinery localization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	IDA	27545678
cytoplasm	IBA
intermediate filament cytoskeleton	IEA
cortical granule	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein-arginine deiminase activity	IDA	38656308 39286527
protein-arginine deiminase activity	IBA
calcium ion binding	IEA
protein binding	IPI	32296183
identical protein binding	IDA	38656308 39286527

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [inference]

protein-arginine deiminase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein-arginine deiminase

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
hydrolase activity
protein-arginine deiminase activity

Displaying **all 7** entries
InterPro
Cupredoxin
PAD, N-terminal domain superfamily
Protein-arginine deiminase (PAD), N-terminal
Protein-arginine deiminase (PAD), central domain
Protein-arginine deiminase, C-terminal
Protein-arginine deiminase, central domain superfamily
Protein-arginine deiminase