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MIRAGE
Indian hedgehog signaling molecule
Summary
- Gene Symbol
-
- IHH
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Developmental protein
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Golgi apparatus
- Metal-binding
- Palmitate
- Protease
- Reference proteome
- Secreted
- Signal
- Transferase
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q14623 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| skeletal system development | ||
| branching involved in blood vessel morphogenesis | ||
| osteoblast differentiation | ||
| in utero embryonic development | ||
| cell fate specification |
GO Hierarchy
- regulation of growth
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| extracellular region | ||
| extracellular space | ||
| endoplasmic reticulum membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| patched binding | ||
| patched binding | ||
| patched binding | ||
| calcium ion binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- hedgehog
- Functional Category
-
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| Gene Ontology |
|---|
| calcium ion binding |
| cell fate specification |
| cell-cell signaling |
| hydrolase activity |
| intein-mediated protein splicing |
| metal ion binding |
| patched binding |
| protein autoprocessing |
| proteolysis |
| regulation of gene expression |
| InterPro |
|---|
| Hedgehog protein, Hint domain |
| Hedgehog protein |
| Hedgehog, N-terminal signalling domain |
| Hint domain C-terminal |
| Hint domain N-terminal |
| Hint domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050604 | acrocapitofemoral dysplasia | |
| DOID:0110964 | brachydactyly type A1 | |
| DOID:0111816 | syndactyly type 1 | |
| DOID:13025 | retinopathy of prematurity |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3549 | Xenbase:XB-GENE-484187 | ||
| 6469 | FB:FBgn0004644 | ||
| 16147 | Xenbase:XB-GENE-484187 | MOUSE30970 | |
| 20423 | FB:FBgn0004644 | ||
| 29499 | FB:FBgn0004644 | ||
| 84399 | RATNO43283 | ||
| 180349 | Xenbase:XB-GENE-484187 | ||
| 180638 | ZFIN:ZDB-GENE-980526-135 | ||
| 181300 | ZFIN:ZDB-GENE-051010-1 | ||
| 397174 | PIGXX10015 |
