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interleukin 1 receptor antagonist

Summary

Gene Symbol

IL1RN

Organism

Homo sapiens (human)

External Links

NCBI Gene

3557

PubChem

3557

Alliance of Genome Resources

HGNC:6000

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Pharmaceutical
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P18510	ICIL-1RA IL1 inhibitor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
negative regulation of cytokine-mediated signaling pathway	IEA
inflammatory response to antigenic stimulus
lipid metabolic process	IEA
acute-phase response	IDA	9185517
inflammatory response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

inflammatory response to antigenic stimulus

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

inflammatory response to antigenic stimulus

acute inflammatory response [inference]

acute-phase response

immune response

inflammatory response to antigenic stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of heterotypic cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion involved in gastrulation [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	10443688 12483741 2137200 9185517
extracellular space	IBA
nucleoplasm	IDA
centrosome	IDA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytokine activity	IEA
interleukin-1 receptor binding	IDA	2137200
interleukin-1, type I receptor binding	IPI	1828071
interleukin-1, type II receptor binding	IPI	1830582
interleukin-1 receptor antagonist activity	TAS	7629520

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-1 receptor binding

interleukin-1 receptor antagonist activity

receptor ligand activity [inference]

cytokine activity

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

growth factor receptor binding [inference]

interleukin-1 receptor binding

growth factor binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

cytokine binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-1 receptor antagonist protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cytokine activity
immune response
inflammatory response to antigenic stimulus
inflammatory response
interleukin-1 receptor antagonist activity
interleukin-1 receptor binding
negative regulation of interleukin-1-mediated signaling pathway

Displaying **all 3** entries
InterPro
Cytokine IL1/FGF
Interleukin-1 family
Interleukin-1 receptor antagonist/Interleukin-36

Disease

Disease Ontology

Displaying entries **61 - 64** of 64 in total

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DO ID	Disease Name	Source
DOID:9538	multiple myeloma	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:986	alopecia areata	Alliance of Genome Resources
DOID:9938	dacryocystitis	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 47** of 47 in total

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Species	Gene ID	Orthologous MAtrix
Crocodylus porosus	109317366	CROPO24703
Vulpes vulpes	112916649	VULVU09237
Pseudonaja textilis	113445758	PSETE18887
Bos indicus x Bos taurus	113901273	BOBOX20137
Rhinolophus ferrumequinum	117019343	RHIFE33481
Panthera leo	122216315	PANLE01205
Ursus americanus	123799738	URSAM10645

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements