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interleukin 10 receptor subunit alpha

Summary

Gene Symbol

IL10RA

Organism

Homo sapiens (human)

External Links

NCBI Gene

3587

PubChem

3587

Alliance of Genome Resources

HGNC:5964

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13651	CDw210a Interleukin-10 receptor subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
negative regulation of autophagy	IDA	26962683
cytokine-mediated signaling pathway	IBA
response to lipopolysaccharide	IEA
positive regulation of receptor signaling pathway via JAK-STAT	IDA	16982608
negative regulation of inflammatory response	IDA	24367025

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-10-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium [inference]

intestinal epithelial structure maintenance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium [inference]

intestinal epithelial structure maintenance

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium [inference]

intestinal epithelial structure maintenance

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

organic substance transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

nitrogen compound transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-10-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular component organization [inference]

regulation of synapse organization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytosol	IDA
plasma membrane	TAS
plasma membrane	IC	16982608
plasma membrane	IDA	22087322

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
interleukin-10 receptor activity	IDA	16982608 24367025
interleukin-10 receptor activity	IBA
protein binding	IPI	11485736 12093920 12513909 15837194 16982608 18395809 20462497 22087322 24008843 32296183
interleukin-10 binding	IEA
signaling receptor activity	TAS	8407942

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

interleukin-10 binding

cytokine binding [inference]

interleukin-10 binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interleukin-10 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-10 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-10 receptor subunit alpha

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
interleukin-10 receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interferon/interleukin receptor domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110899	inflammatory bowel disease 28	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 63 in total

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Species	Gene ID	Orthologous MAtrix
Cavia porcellus	100727507	CAVPO10029
Sarcophilus harrisii	100926905	SARHA10187
Otolemur garnettii	100962082	OTOGA06122
Pan paniscus	100982658	PANPA08047
Papio anubis	101014353	PAPAN06467
Saimiri boliviensis boliviensis	101032801	SAIBB06493
Felis catus	101087601	FELCA25898
Ovis aries	101120946	SHEEP06127
Gorilla gorilla gorilla	101153778	GORGO03001
Jaculus jaculus	101605451	JACJA19337

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements