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interleukin 16

Summary

Gene Symbol

IL16

Organism

Homo sapiens (human)

External Links

NCBI Gene

3603

PubChem

3603

Alliance of Genome Resources

HGNC:5980

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Chemotaxis
Cytokine
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome
Repeat
Secreted
Transcription regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q14005
Q9UME6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
immune response	TAS	9144227
cytokine-mediated signaling pathway	ISS	30089723
cytokine-mediated signaling pathway	IBA
leukocyte chemotaxis	IEA
positive regulation of interleukin-1 alpha production	IDA	30634164

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IEA
cytosol	TAS
cytosol	IDA
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

nuclear body [inference]

nuclear speck

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

Flemming body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytokine activity	IBA
protein binding	IPI	32296183 32814053
CD4 receptor binding	IBA
CD4 receptor binding	IPI	24942581

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

CD4 receptor binding

receptor ligand activity [inference]

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pro-interleukin-16

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytokine activity

Displaying **all 2** entries
InterPro
PDZ domain
PDZ superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100013058	MONDO03044
Taeniopygia guttata	100231177	TAEGU01870
Callithrix jacchus	100405604	CALJA37385
Pongo abelii	100439413	PONAB09265
Ailuropoda melanoleuca	100467740	AILME12915
Danio rerio	100534674	DANRE41112
Meleagris gallopavo	100543883	MELGA03166
Nomascus leucogenys	100584587	NOMLE32909
Cavia porcellus	100721175	CAVPO06683
Sarcophilus harrisii	100917626	SARHA06427

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements