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aquaporin 4

Summary

Gene Symbol

AQP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

361

PubChem

361

Alliance of Genome Resources

HGNC:637

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Disease variant
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 4** entries
UniProt	Protein Name
V9PBN7
F1DSG4
A0A5F9ZHR4
P55087	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
renal water homeostasis	TAS
water transport	IDA	19383790 8601457
water transport	IBA
intracellular water homeostasis	ISS
intracellular water homeostasis	IMP	37143309

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

nervous system process [inference]

cerebrospinal fluid circulation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

fluid transport [inference]

water transport

transmembrane transport

organic substance transport [inference]

water transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

renal water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IDA	18392839
plasma membrane	TAS
plasma membrane	IDA	16814974 37143309 8601457
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25910212 28734904 31286866 32296183
water channel activity	EXP	17178220 18511455
water channel activity	IDA	19383790 8601457
water channel activity	IMP	37143309
water channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

water channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080315	megalencephalic leukoencephalopathy with subcortical cysts	Alliance of Genome Resources
DOID:0080743	transverse myelitis	Alliance of Genome Resources
DOID:1210	optic neuritis	Alliance of Genome Resources
DOID:1432	blindness	Alliance of Genome Resources
DOID:3328	temporal lobe epilepsy	Alliance of Genome Resources
DOID:8869	neuromyelitis optica	Alliance of Genome Resources
DOID:9849	Meniere's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **116** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	358	SGD:S000006396
Saccharomyces cerevisiae S288C	359	SGD:S000006396
Xenopus tropicalis	361	Xenbase:XB-GENE-5993458
Saccharomyces cerevisiae S288C	362	SGD:S000006396
Saccharomyces cerevisiae S288C	11826	SGD:S000006396
Saccharomyces cerevisiae S288C	11827	SGD:S000006396
Mus musculus	11829	Xenbase:XB-GENE-5993458	MOUSE24683
Saccharomyces cerevisiae S288C	11830	SGD:S000006396
Saccharomyces cerevisiae S288C	11831	SGD:S000006396
Saccharomyces cerevisiae S288C	25240	SGD:S000006396

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements