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LARGE xylosyl- and glucuronyltransferase 1

Summary

Gene Symbol

Large1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

361368

KEGG Gene ID

rno:361368

PubChem

361368

Alliance of Genome Resources

RGD:1308895

Annotation

Keyword

Glycoprotein
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A6JY89

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **71 - 72** of 72 in total

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GO Term	Evidence Code	PMID
basement membrane organization	ISO
neuromuscular synaptic transmission	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein modification process

protein phosphorylation

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein modification process

protein phosphorylation

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein modification process

protein phosphorylation

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process

protein phosphorylation

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein modification process

protein phosphorylation

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

glial cell differentiation [inference]

astrocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

skeletal muscle fiber differentiation

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac cell development [inference]

cardiac muscle cell development

cell motility [inference]

cell migration [inference]

neuron migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

localization of cell

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

protein-containing complex assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

synapse organization

synapse assembly [inference]

synaptic assembly at neuromuscular junction

neuromuscular junction development

synaptic assembly at neuromuscular junction

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

protein-containing complex organization [inference]

protein-containing complex assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

membrane organization [inference]

plasma membrane organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

cognition [inference]

learning or memory [inference]

memory

neuromuscular process

neuromuscular process controlling posture

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

memory

locomotory behavior [inference]

walking behavior

determination of adult lifespan

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

multicellular organism growth

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

appendage morphogenesis [inference]

limb morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

hindlimb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

post-embryonic appendage morphogenesis [inference]

post-embryonic limb morphogenesis [inference]

post-embryonic hindlimb morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

blood vessel development

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

connective tissue development

regeneration [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac cell development [inference]

cardiac muscle cell development

animal organ development [inference]

muscle organ development

skeletal muscle organ development

bone development

system development [inference]

vasculature development [inference]

retina vasculature development in camera-type eye

appendage development [inference]

limb development

neural nucleus development [inference]

trigeminal sensory nucleus development [inference]

principal sensory nucleus of trigeminal nerve development

retina development in camera-type eye

muscle structure development [inference]

muscle organ development

skeletal muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

glial cell differentiation [inference]

astrocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

skeletal muscle fiber differentiation

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cardiac cell development [inference]

cardiac muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

tissue regeneration [inference]

skeletal muscle tissue regeneration

synaptic assembly at neuromuscular junction

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

inflammatory response [inference]

neuroinflammatory response [inference]

reactive gliosis

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

fluid transport [inference]

water transport

intracellular transport [inference]

intracellular protein transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

organic substance transport [inference]

water transport

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane

protein localization to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

localization of cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of kinase activity

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of kinase activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of biological quality [inference]

regulation of synaptic plasticity

long-term synaptic potentiation

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IBA ISO
protein-containing complex	ISO
intracellular membrane-bounded organelle	ISO
plasma membrane	ISO
neuromuscular junction	ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
xylosyltransferase activity	IBA ISO
manganese ion binding	ISO
glycosyltransferase activity	ISO
hexosyltransferase activity	ISO
glucuronosyltransferase activity	IBA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity

glucuronosyltransferase activity

pentosyltransferase activity [inference]

xylosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

LARGE xylosyl- and glucuronyltransferase 1

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
UDP-glycosyltransferase activity
protein O-linked mannosylation
xylosyltransferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase, family 8
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K09668

Name

glycosyltransferase-like protein LARGE [EC:2.4.2.- 2.4.1.-]

References

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050588	muscular dystrophy-dystroglycanopathy type B1	Alliance of Genome Resources
DOID:0110637	muscular dystrophy-dystroglycanopathy type B6	Alliance of Genome Resources
DOID:0111242	congenital muscular dystrophy-dystroglycanopathy type A6	Alliance of Genome Resources
DOID:11727	facioscapulohumeral muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9215		HGNC:6511	HUMAN60185
Mus musculus	16795	10090_1:00283d	MGI:1342270	MOUSE59870
Caenorhabditis elegans	187206		WB:WBGene00010716
Danio rerio	446213		ZFIN:ZDB-GENE-061204-1	DANRE35049
Pan troglodytes	470192			PANTR26426
Canis lupus familiaris	474521			CANLF01677
Bos taurus	506466			BOVIN29900
Macaca mulatta	717403			MACMU02184
Monodelphis domestica	100016258			MONDO33219
Equus caballus	100068935			HORSE26243

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Last updated: December 9, 2024