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MIRAGE

BSCL2 lipid droplet biogenesis associated, seipin

Summary

Gene Symbol

Bscl2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

361722

PubChem

361722

Alliance of Genome Resources

RGD:1308135

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Lipid degradation
Lipid droplet
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5FVJ6	Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISO
tissue homeostasis	ISO
hair follicle development	ISO
lipid metabolic process	IEA
mitochondrion organization	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

maintenance of location in cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

lipid droplet organization

lipid droplet formation

chromosome organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

multicellular organismal process [inference]

determination of adult lifespan

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

multicellular organism growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

anatomical structure development [inference]

hair follicle development

tissue development [inference]

connective tissue development [inference]

adipose tissue development

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

localization [inference]

maintenance of location [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

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GO Term	Evidence Code	PMID
cytoplasm	ISO
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipid binding	ISO
phospholipid binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Seipin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
lipid droplet formation
lipid droplet organization
lipid metabolic process
lipid storage

Displaying 1 entry
InterPro
Seipin family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14227	azoospermia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14705	Xenbase:XB-GENE-956631	MOUSE25857
Homo sapiens	26580	Xenbase:XB-GENE-956631	HUMAN06619
Xenopus tropicalis	361722	Xenbase:XB-GENE-956631
Canis lupus familiaris	476054		CANLF06158
Bos taurus	513558		BOVIN23295
Monodelphis domestica	100012298		MONDO26975
Equus caballus	100063764		HORSE06227
Sus scrofa	100144883		PIGXX16974
Pongo abelii	100172848		PONAB02494
Oryctolagus cuniculus	100339598		RABIT14613

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025